THOC2 - THO complex subunit 2 Gene

Also Known as THO2; MRX12; MRX35; CXorf3; XLID12; hTREX120; dJ506G2.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57187

About THOC2

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:123,600,569-123,733,052 (from NCBI)

This gene has 20 transcripts (splice variants), 231 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues.

Summary

The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]

THOC2 Products (1)

mRNA Protein Name
NM_001081550.2 NP_001075019.1 THO complex subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15870275 GOA
Biological Process GO Annotation Evidence References Source
involved in generation of neurons IMP
IMP: Inferred from mutant phenotype
26166480 GOA
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
17190602 GOA
involved in neuron development IMP
IMP: Inferred from mutant phenotype
26166480 GOA
involved in poly(A)+ mRNA export from nucleus IDA
IDA: Inferred from direct assay
22928037 GOA
Cellular Component GO Annotation Evidence References Source
part of THO complex IDA
IDA: Inferred from direct assay
15998806 GOA
part of THO complex part of transcription export complex IDA
IDA: Inferred from direct assay
15998806 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
15833825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC2 Protein Structure

Thoc2

Thoc2: Transcription- and export-related complex subunit (568 - 644)

Tho2

Tho2: Transcription factor/nuclear export subunit protein 2 (871 - 1174)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1593 a.a.
Protein Preferred Names Protein Names

THO complex subunit 2

  • THO complex 2

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, X-Linked 12

  • XLID12

  • Mrx12

  • Mental Retardation, X-Linked 35

  • Mrx35

  • Mental Retardation, X-Linked 12
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

  • Mrx12

  • Mrx35

  • X-Linked Mental Retardation 12

  • X-Linked Mental Retardation 35
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome 1

  • LCCS1

  • Multiple Contracture Syndrome, Finnish Type

  • Lccs

  • Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures

  • Lethal Congenital Contracture Syndrome Type 1

  • Herva Disease

  • Multiple Contracture Syndrome Finnish Type

  • Contracture Syndrome, Lethal, Congenital, Type 1
Spinal Muscular Atrophy, Type I

  • Werdnig-Hoffmann Disease

  • SMA1

  • Spinal Muscular Atrophy 1

  • Sma I

  • Sma, Infantile Acute Form

  • Muscular Atrophy, Infantile

  • Spinal Muscular Atrophy-1

  • Hmn Proximal Type I

  • Infantile Muscular Atrophy

  • Proximal Spinal Muscular Atrophy Type 1

  • Sma Type 1

  • Sma Type I

  • Sma-I

  • Hereditary Motor Neuropathy Proximal Type I

  • Progressive Muscular Atrophy Of Infancy

  • Proximal Spinal Muscular Atrophy, Type 1

  • Werdnig Hoffmann Disease

  • Infantile Spinal Muscular Atrophy

  • Infantile-Onset Spinal Muscular Atrophy

  • Proximal Hereditary Motor Neuropathy Type I

  • Sma Infantile Acute Form

  • Spinal Muscular Atrophy Type I

  • Werdnig-Hoffman Disease

  • Atrophy, Muscular, Spinal, Type 1
Lethal Congenital Contracture Syndrome

  • Lccs

  • Lethal Congenital Contracture Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14492 THOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus THOC2 VGNC VGNC:66167
Rattus norvegicus THOC2 RGD RGD:1561623
Canis familiaris THOC2 VGNC VGNC:47349
Mus musculus THOC2 MGD MGI:2442413
Macaca mulatta THOC2 VGNC VGNC:79177
Others THOC2 NCBI