2. Gene
  3. USP35 - ubiquitin specific peptidase 35 Gene

USP35 - ubiquitin specific peptidase 35 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57558 | Gene type: protein coding

About USP35

This gene has 7 transcripts (splice variants), 131 orthologues and 71 paralogues. Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a MicroRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

USP35 Products(1)

mRNA Protein Name
NM_020798.4 NP_065849.1 ubiquitin carboxyl-terminal hydrolase 35

USP35 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (441 - 923)

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  • 1018 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 35

deubiquitinating enzyme 35

Related Diseases

Diseases Alias
Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15546 USP35 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP35 VGNC VGNC:36725
Rattus norvegicus USP35 RGD RGD:1565984
Canis familiaris USP35 VGNC VGNC:48191
Felis catus USP35 VGNC VGNC:66881
Macaca mulatta USP35 VGNC VGNC:79218
Mus musculus USP35 MGD MGI:2685339