USP35 - ubiquitin specific peptidase 35 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57558

About USP35

This gene has 7 transcripts (splice variants), 131 orthologues and 71 paralogues. Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating Enzymes (DUBs) catalyze the removal of ubiquitin proteins from Other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a MicroRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

USP35 Products (1)

mRNA Protein Name
NM_020798.4 NP_065849.1 ubiquitin carboxyl-terminal hydrolase 35

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP35 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (441 - 923)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1018 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 35

  • deubiquitinating enzyme 35

Related Diseases

Diseases Alias
Juvenile-Onset Parkinson'S Disease

  • Juvenile-Onset Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15546 USP35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20510 Usp35 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27019 Usp35 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP35 VGNC VGNC:36725
Rattus norvegicus USP35 RGD RGD:1565984
Canis familiaris USP35 VGNC VGNC:48191
Felis catus USP35 VGNC VGNC:66881
Macaca mulatta USP35 VGNC VGNC:79218
Mus musculus USP35 MGD MGI:2685339
Others USP35 NCBI