Nectin1 - nectin cell adhesion molecule 1 Gene

Also Known as PRR; HIgR; HveC; PRR1; Cd111; Pvrl1; nectin-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 58235

Summary

Enables protein homodimerization activity and signaling receptor activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including camera-type eye development; desmosome organization; and enamel mineralization. Located in adherens junction; apical junction complex; and cell-cell contact zone. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic active zone membrane. Is expressed in brain; oral region epithelium; sensory organ; skin; and upper jaw molar. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Nectin1 Products (1)

mRNA	Protein	Name
NM_021424.3	NP_067399.2	nectin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12826663	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12826663	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	11090177	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	15728677	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18703497	MGI
acts upstream of or within desmosome organization	IMP IMP: Inferred from mutant phenotype	18703497	MGI
acts upstream of or within enamel mineralization	IMP IMP: Inferred from mutant phenotype	18703497	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12826663	MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	12826663	MGI
acts upstream of or within iron ion transport	IMP IMP: Inferred from mutant phenotype	18703497	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	15728677	MGI
acts upstream of or within protein localization to cell junction	IDA IDA: Inferred from direct assay	22512338	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	15728677	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12515806	MGI
located in apical junction complex	IDA IDA: Inferred from direct assay	22512338	MGI
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23533177	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	11827984	MGI
is active in hippocampal mossy fiber to CA3 synapse	IEP IEP: Inferred from expression pattern	11827984	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	11827984	MGI
is active in presynaptic active zone membrane	IEP IEP: Inferred from expression pattern	11827984	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nectin-1	herpes virus entry mediator C herpesvirus entry mediator C nectin-1 alpha nectin-1 delta poliovirus receptor-related protein 1

Recombinant Nectin1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77468	Nectin-1 Protein, Mouse (HEK293, Fc)	Q9JKF6 (Q31-A354)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77469	Nectin-1 Protein, Mouse (HEK293, His)	Q9JKF6 (Q31-A354)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09174	NECTIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20215	Nectin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26721	Nectin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nectin1	NCBI	NCBI:5818