Nectin-1 Protein, Mouse (HEK293, Fc)
Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-hFc labeled tag.
Background
Nectin-1, a pivotal player in cell adhesion and synaptogenesis, exhibits neurite outgrowth-promoting activity, underscoring its importance in neurodevelopmental processes. Functioning as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus, Nectin-1 facilitates viral entry into cells. The protein engages in both cis- and trans-homodimerization and can also form trans-heterodimers with NECTIN3, initiating the formation of puncta adherentia junctions crucial for axon-dendrite interactions. Additionally, its interaction with FGFR1, FGFR2, and FGFR3, as well as AFDN, establishes connections with the actin cytoskeleton, contributing to its diverse cellular roles. Notably, Nectin-1 interacts with HSV glycoprotein D (gD), highlighting its involvement in viral infection processes.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-hFc
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Accession
Q9JKF6 (Q31-A354)
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Molecular Construction
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N-term
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Nectin-1 (Q31-A354)
Accession # Q9JKF6 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
NECTIN1; OFC7; Prev. PVRL1; Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C); Prev. HVEC; Herpesvirus Ig-Like Receptor; Prev. ED4; Ectodermal Dysplasia 4 (Margarita Island Type); Nectin-1; Herpes Simplex Virus Type 1 Sensitivity; PRR1; Herpesv
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AA Sequence
QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRPSFIDGTIRLSGLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTRAVLRARKGQDDKVLVATCTSANGKPPSAVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPITYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPTPEHGRRAGQMPTA
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Predicted Molecular Mass
62.9 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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