Tgfb1 - transforming growth factor, beta 1 Gene

Also Known as Tgfb

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59086

About Tgfb1

Primary_assembly 1: 81,196,532-81,212,847 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 210 orthologues, 31 paralogues and is associated with 174 phenotypes. Biased expression in Spleen (RPKM 118.3), Thymus (RPKM 42.1) and 6 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb1 Products (1)

mRNA Protein Name
NM_021578.2 NP_067589.1 transforming growth factor beta-1 proprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18406405 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18406405 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
9699514 RGD
involved in cellular response to acetaldehyde IEP
IEP: Inferred from expression pattern
12223100 RGD
involved in cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17537984 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32065356 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
25335926 RGD
involved in cellular response to ionizing radiation IEP
IEP: Inferred from expression pattern
25600523 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19012730 RGD
involved in defense response to fungus IDA
IDA: Inferred from direct assay
16272332 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
12815632 RGD
involved in epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
10504497 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
15927076 RGD
involved in frontal suture morphogenesis IEP
IEP: Inferred from expression pattern
12416537 RGD
involved in inner ear development IEP
IEP: Inferred from expression pattern
16479080 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
25862490 RGD
involved in morphogenesis of a branching structure IDA
IDA: Inferred from direct assay
15192047 RGD
involved in myelination IMP
IMP: Inferred from mutant phenotype
14648590 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
15192047 RGD
involved in negative regulation of neuroblast proliferation IDA
IDA: Inferred from direct assay
16177030 RGD
involved in negative regulation of phagocytosis IDA
IDA: Inferred from direct assay
16272332 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
12876066 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
29175126 RGD
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15781474 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16157589 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16532270 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17537984 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
26923362 RGD
involved in positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
15192047 RGD
involved in positive regulation of exit from mitosis IDA
IDA: Inferred from direct assay
16177030 RGD
involved in positive regulation of mononuclear cell migration IMP
IMP: Inferred from mutant phenotype
26923362 RGD
acts upstream of or within positive regulation of smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
8616889 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
23393573 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15746252 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
29399060 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
18587447 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17213961 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
25641164 RGD
involved in response to laminar fluid shear stress IEP
IEP: Inferred from expression pattern
16217485 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15746252 RGD
involved in response to salt IEP
IEP: Inferred from expression pattern
23249995 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
11956143 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11597910 RGD
involved in transforming growth factor beta receptor signaling pathway IEP
IEP: Inferred from expression pattern
33360052 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15214860 RGD
located in cell surface IDA
IDA: Inferred from direct assay
10487979 RGD
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
24224514 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16837651 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15214860 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15214860 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb1 Protein Structure

TGFb_propeptide

TGFb_propeptide: pfam00688 (29 - 260)

TGF_beta_TGFB1

TGF_beta_TGFB1: cd19384 (291 - 389)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta-1 proprotein

  • TGF-beta-1

Recombinant Tgfb1 Proteins

Cat. No. Product Name Accession Purity
HY-P73615 Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, His) P17246 (L30-S390) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99305 Metelimumab Inhibitor 98.98% Phase 2
HY-P991382 SAR-439459 Inhibitor 99.41% Phase 2
HY-P991383 LY2382770 Inhibitor / Phase 2
HY-P991950 SHR-1906 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14435 TGFB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W764758 3-OH-Kynurenamine dihydroiodide Activator 99.56% Unkown
HY-RS14436 Tgfb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-156908 3-OH-Kynurenamine Activator / Unkown
HY-RS14437 Tgfb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14438 TGFB1I1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174534 Human TGFB1 mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99606 Cirevetmab Inhibitor ≥99.0% Unkown
HY-P990517 Anti-TGFb1 Antibody Inhibitor 98.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb1 NCBI NCBI:7040