Sik1 - salt-inducible kinase 1 Gene

Also Known as Sik; Snf1lk

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 59329

About Sik1

Primary_assembly 20: 9,947,396-9,958,991 reverse strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 236 orthologues, 26 paralogues and is associated with 15 phenotypes. Biased expression in Lung (RPKM 8.3), Spleen (RPKM 72.) and 9 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in negative regulation of transcription by RNA polymerase II; protein phosphorylation; and regulation of sodium ion transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sik1 Products (1)

mRNA	Protein	Name
NM_021693.3	NP_067725.2	serine/threonine-protein kinase SIK1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17939993	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17939993	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17939993	RGD
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	12530631	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12530631	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12530631	RGD
involved in regulation of sodium ion transport	IDA IDA: Inferred from direct assay	17939993	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sik1 Protein Structure

STKc_SIK

UBA_SIK1

0
200
400
600
776 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase SIK1	SIK-1 SNF1-like kinase protein kinase KID2 salt-inducible protein kinase 1 serine/threonine-protein kinase SNF1-like kinase 1 serine/threonine-protein kinase SNF1LK

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15776	HG-9-91-01	Inhibitor	99.77%	Unkown
HY-101147	YKL-05-099	Inhibitor	99.76%	Unkown
HY-120877	MRT199665	Inhibitor	99.85%	Unkown
HY-120856	ARN-3236	Inhibitor	99.66%	Unkown
HY-120056	YKL-06-061	Inhibitor	99.82%	Unkown
HY-175479	GLPG4970	Inhibitor	99.60%	Unkown
HY-139253	MRIA9	Inhibitor	98.88%	Unkown
HY-171591	SIK2-IN-4	Inhibitor	99.06%	Unkown
HY-182804	SIK2/3-IN-3	Inhibitor	/	Unkown
HY-171590	SIK2-IN-3	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sik1	NCBI	NCBI:150094