CHP2 - calcineurin like EF-hand protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63928

About CHP2

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 110.6), small intestine (RPKM 92.6) and 2 other tissues.

Summary

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with Calcineurin B and can bind to and stimulate the protein Phosphatase activity of Calcineurin A (CnA) and functions in the Calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of Calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

CHP2 Products (1)

mRNA Protein Name
NM_022097.4 NP_071380.1 calcineurin B homologous protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
21392185 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16710297 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of phosphatase activity IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18815128 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21392185 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21392185 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21392185 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHP2 Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (31 - 54)

EF-hand_7

EF-hand_7: EF-hand domain pair (115 - 138)

EF-hand_5

EF-hand_5: EF hand (160 - 178)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

calcineurin B homologous protein 2

  • hepatocellular carcinoma antigen gene 520

CHP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHP2 O43745 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
CHP2 O43745 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
CHP2 O43745 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
CHP2 O43745 SLC9A1 Homo sapiens P19634
ITC
31912575
Intra
CHP2 O43745 SLC9A1 Homo sapiens P19634
Anti Tag CoIP
33961781
Intra
CHP2 O43745 SLC9A1 Homo sapiens P19634
Fluorescence
31912575
Intra
CHP2 O43745 SLC9A1 Homo sapiens P19634
Biophysical
16710297
Intra
CHP2 O43745 SLC9A1 Homo sapiens P19634
MST
31912575
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Macs Syndrome

  • Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis

  • Mycobacterium Avium Complex Disease

  • Rin2 Syndrome

  • Mycobacterium Avium-Intracellulare Infection

  • Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis

  • Mycobacterium Avium Complex

  • Mycobacterium Avium Infection

  • Infection Due To Mycobacterium Intracellulare

  • Mac Disease

  • Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome

  • Rin2 Deficiency

  • Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome

  • MACS

  • Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02653 CHP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHP2 VGNC VGNC:54012
Mus musculus CHP2 MGD MGI:1917511
Macaca mulatta CHP2 VGNC VGNC:104688
Bos taurus CHP2 VGNC VGNC:27311
Rattus norvegicus CHP2 RGD RGD:727796
Felis catus CHP2 VGNC VGNC:107749
Others CHP2 NCBI