NPFFR1 - neuropeptide FF receptor 1 Gene

Also Known as NPFF1; GPR147; NPFF1R1; OT7T022

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64106

About NPFFR1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,247,329-70,284,004 (from NCBI)

This gene has 1 transcript (splice variant), 237 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium. [provided by Alliance of Genome Resources, Apr 2022]

NPFFR1 Products (1)

mRNA Protein Name
NM_022146.5 NP_071429.1 neuropeptide FF receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide receptor activity IDA
IDA: Inferred from direct assay
11024015 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
11024015 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
11024015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPFFR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 430 a.a.
Protein Preferred Names Protein Names

neuropeptide FF receptor 1

  • G-protein coupled receptor 147

NPFFR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPFFR1 Q9GZQ6 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
NPFFR1 Q9GZQ6 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
NPFFR1 Q9GZQ6 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
NPFFR1 Q9GZQ6 ATP1A3 Homo sapiens P13637
Y2H Pooling
32814053
Intra
NPFFR1 Q9GZQ6 ATP1A3 Homo sapiens P13637
Validated Y2H
32814053
Intra
NPFFR1 Q9GZQ6 ATP1A3 Homo sapiens P13637
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1248 Neuropeptide FF 99.35% Unkown
HY-161405 NPFF1-R antagonist 1 Inhibitor 99.38% Unkown
HY-P10394 DP32 Antagonist / Unkown
HY-P10395 DP50 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NPFFR1 MGD MGI:2685082
Rattus norvegicus NPFFR1 RGD RGD:621570
Bos taurus NPFFR1 VGNC VGNC:32199
Others NPFFR1 NCBI