2. Gene
  3. ERAP2 - endoplasmic reticulum aminopeptidase 2 Gene

ERAP2 - endoplasmic reticulum aminopeptidase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as LRAP; L-RAP

Gene ID: 64167 | Gene type: protein coding

About ERAP2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:96,875,939-96,919,716 (from NCBI)

This gene has 11 transcripts (splice variants), 170 orthologues and 11 paralogues. Broad expression in lymph node (RPKM 22.9), spleen (RPKM 19.0) and 23 other tissues.

Summary

This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related Aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]

ERAP2 Products(4)

mRNA Protein Name
NM_001130140.2 NP_001123612.1 endoplasmic reticulum aminopeptidase 2 isoform 1
NM_001329229.1 NP_001316158.1 endoplasmic reticulum aminopeptidase 2 isoform 2
NM_001329233.1 NP_001316162.1 endoplasmic reticulum aminopeptidase 2 isoform 3
NM_022350.5 NP_071745.1 endoplasmic reticulum aminopeptidase 2 isoform 1

ERAP2 Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (68 - 458)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (620 - 937)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 960 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum aminopeptidase 2

leukocyte-derived arginine aminopeptidase

Recombinant ERAP2 Proteins

Cat. No. Product Name Accession Purity
HY-P75756 ERAP2 Protein, Human (HEK293, His) Q6P179-1/NP_071745.1 (A56-T960) ≥95%

Related Diseases

Diseases Alias
Spondylitis
Eclampsia

Eclampsia In Puerperium

Postpartum Eclampsia

Eclampsia, Postpartum

Puerperal Eclampsia
Birdshot Chorioretinopathy

Birdshot Chorioretinitis

Bscr

Birdshot Retinochoroiditis

Birdshot Retinochoroidopathy

Vitiliginous Choroiditis

Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Immunodeficiency 48

Combined Immunodeficiency Due To Zap70 Deficiency

IMD48

Selective T-Cell Defect

Stcd

Zeta-Associated-Protein 70 Deficiency

Severe Combined Immunodeficiency, Atypical

Immunodeficiency, Type 48

Zap70 Deficiency
Posterior Uveitis

Uveitis, Posterior

Choroiditis

Uveitis Posterior
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Panuveitis

Diffuse Uveitis

Total Uveitis

Inflammation Of The Whole Uveal Tract
Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive
Anterior Uveitis

Iridocyclitis

Uveitis, Anterior

Acute Anterior Uveitis

Uveokeratitis

Keratouveitis

Cyclitis

Intraocular Inflammation

Kerato-Uveitis

Keratoiritis

Iritis

Uveitis Nos

Uveal Inflammation

Anterior Chamber Cell
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150504 ERAP2-IN-1 98.86% Unkown
HY-139907 DG013A / Unkown
HY-RS04464 ERAP2 Human Pre-designed siRNA Set A / Unkown