ERAP2 - endoplasmic reticulum aminopeptidase 2 Gene

Also Known as LRAP; L-RAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64167

About ERAP2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:96,875,939-96,919,716 (from NCBI)

This gene has 11 transcripts (splice variants), 170 orthologues and 11 paralogues. Broad expression in lymph node (RPKM 22.9), spleen (RPKM 19.0) and 23 other tissues.

Summary

This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related Aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]

ERAP2 Products (4)

mRNA Protein Name
NM_001130140.2 NP_001123612.1 endoplasmic reticulum aminopeptidase 2 isoform 1
NM_001329229.1 NP_001316158.1 endoplasmic reticulum aminopeptidase 2 isoform 2
NM_001329233.1 NP_001316162.1 endoplasmic reticulum aminopeptidase 2 isoform 3
NM_022350.5 NP_071745.1 endoplasmic reticulum aminopeptidase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
12799365 GOA
enables endopeptidase activity EXP
EXP: Inferred from Experiment
12436109 GOA
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
12799365 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15908954 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
12799365 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERAP2 Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (68 - 458)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (620 - 937)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 960 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum aminopeptidase 2

  • leukocyte-derived arginine aminopeptidase

Recombinant ERAP2 Proteins

Cat. No. 상품명 Accession Purity
HY-P75756 ERAP2 Protein, Human (HEK293, His) Q6P179-1/NP_071745.1 (A56-T960) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spondylitis
Eclampsia

  • Eclampsia In Puerperium

  • Postpartum Eclampsia

  • Eclampsia, Postpartum

  • Puerperal Eclampsia
Birdshot Chorioretinopathy

  • Birdshot Chorioretinitis

  • Bscr

  • Birdshot Retinochoroiditis

  • Birdshot Retinochoroidopathy

  • Vitiliginous Choroiditis

  • Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Immunodeficiency 48

  • Combined Immunodeficiency Due To Zap70 Deficiency

  • IMD48

  • Selective T-Cell Defect

  • Stcd

  • Zeta-Associated-Protein 70 Deficiency

  • Severe Combined Immunodeficiency, Atypical

  • Immunodeficiency, Type 48

  • Zap70 Deficiency
Posterior Uveitis

  • Uveitis, Posterior

  • Choroiditis

  • Uveitis Posterior
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Panuveitis

  • Diffuse Uveitis

  • Total Uveitis

  • Inflammation Of The Whole Uveal Tract
Spondyloarthropathy

  • Spondylarthropathies

  • Spondarthropathy

  • Spondylarthrosis

  • Spondyloarthropathy, Susceptibility To

  • Spondylarthritis
Spondyloarthropathy 1

  • Ankylosing Spondylitis

  • Spondyloarthropathy, Susceptibility To, 1

  • SPDA1

  • Marie-Strumpell Spondylitis

  • Bechterew Syndrome

  • Spa

  • Spondylarthritis Ankylopoietica

  • Reiter Syndrome

  • Ankylosing Spondylitis, Susceptibility To

  • Bekhterev Syndrome

  • Bekhterev'S Disease

  • Marie-Strumpell Disease

  • Axial Spondylarthritis

  • Bechterew Disease

  • Marie-Struempell Disease

  • Spondylitis Ankylopoietica

  • Spondyloarthritis

  • Spondyloarthritis Ankylopoietica

  • Spas

  • Ankylosing Spondylarthritis

  • Psoriatic Arthritis

  • Reactive Arthritis

  • Rheumatoid Spondylitis

  • Spondylitis Ankylosans

  • Spondylitis Ankylosing

  • Spondylitis, Ankylosing

  • Spondylarthropathies

  • Arthritis, Psoriatic

  • Arthritis, Reactive
Anterior Uveitis

  • Iridocyclitis

  • Uveitis, Anterior

  • Acute Anterior Uveitis

  • Uveokeratitis

  • Keratouveitis

  • Cyclitis

  • Intraocular Inflammation

  • Kerato-Uveitis

  • Keratoiritis

  • Iritis

  • Uveitis Nos

  • Uveal Inflammation

  • Anterior Chamber Cell
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-139907B DG013A formate Inhibitor 99.57% Unkown
HY-150504 ERAP2-IN-1 Inhibitor 98.86% Unkown
HY-176778A (rac)-BDM88951 Inhibitor 98.64% Unkown
HY-176778 BDM88951 Inhibitor / Unkown
HY-139907C DG013B formate Control / Unkown
HY-139907 DG013A Inhibitor / Unkown
HY-173022 BDM_92499 Inhibitor / Unkown
HY-179625 GSK235 Inhibitor / Unkown
HY-RS04464 ERAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-139907A DG013B Control / Unkown