Gpr88 - G-protein coupled receptor 88 Gene

Also Known as Strg

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64378

About Gpr88

Chromosome 3: 116,043,303-116,047,152 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 147 orthologues, 55 paralogues and is associated with 31 phenotypes. Biased expression in cortex adult (RPKM 16.3), CNS E18 (RPKM 8.2) and 9 other tissues.

Summary

Enables cytoskeletal motor activity. Involved in motor learning. Acts upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Predicted to be located in several cellular components, including cilium; nucleus; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Apr 2022]

Gpr88 Products (8)

mRNA Protein Name
NM_001411424.1 NP_001398353.1 probable G-protein coupled receptor 88
NM_001411426.1 NP_001398355.1 probable G-protein coupled receptor 88
NM_022427.3 NP_071872.1 probable G-protein coupled receptor 88
NM_001411425.1 NP_001398354.1 probable G-protein coupled receptor 88
NM_001411424.1 NP_001398353.1 probable G-protein coupled receptor 88
NM_001411425.1 NP_001398354.1 probable G-protein coupled receptor 88
NM_001411426.1 NP_001398355.1 probable G-protein coupled receptor 88
NM_022427.3 NP_071872.1 probable G-protein coupled receptor 88

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal motor activity IMP
IMP: Inferred from mutant phenotype
26188600 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
23064379 MGI
involved in motor learning IMP
IMP: Inferred from mutant phenotype
26188600 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
23064379 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
23064379 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr88 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 346)

7tm_GPCRs

7tm_GPCRs: cd14964 (33 - 57)

7tm_GPCRs

7tm_GPCRs: cd14964 (66 - 88)

7tm_GPCRs

7tm_GPCRs: cd14964 (113 - 135)

7tm_GPCRs

7tm_GPCRs: cd14964 (159 - 175)

7tm_GPCRs

7tm_GPCRs: cd14964 (189 - 212)

7tm_GPCRs

7tm_GPCRs: cd14964 (282 - 304)

7tm_GPCRs

7tm_GPCRs: cd14964 (314 - 339)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 88

  • striatum-specific G-protein coupled receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112612A RTI-13951-33 hydrochloride 98.56% Unkown
HY-100013A1 (1R,2R)-2-PCCA hydrochloride 98.08% Unkown
HY-100013C 2-PCCA hydrochloride 99.61% Unkown
HY-167856A RTI-122 dihydrochloride Agonist 99.36% Unkown
HY-156771 GPR88-IN-1 Inhibitor 99.17% Unkown
HY-112612 RTI-13951-33 / Unkown
HY-167856 RTI-122 Agonist / Unkown
HY-156772 GPR88 agonist 2 Agonist 99.57% Unkown
HY-100013 2-PCCA Agonist / Unkown
HY-100013B1 (1S,2S)-2-PCCA hydrochloride Control 99.65% Unkown
HY-162660 BI-9508 Agonist / Unkown
HY-163096 GPR88 agonist 3 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr88 NCBI NCBI:54112