2. Gene
  3. Crhr2 - corticotropin releasing hormone receptor 2 Gene

Crhr2 - corticotropin releasing hormone receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Crf2r; CRF-R 2; CRH-R 2

Gene ID: 64680 | Gene type: protein coding

About Crhr2

Primary_assembly 4: 84,224,002-84,265,904 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 203 orthologues, 42 paralogues and is associated with 23 phenotypes. Biased expression in Muscle (RPKM 8.2), Heart (RPKM 5.4) and 5 other tissues.

Summary

Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crhr2 Products(1)

mRNA Protein Name
NM_022714.2 NP_073205.2 corticotropin-releasing factor receptor 2 precursor

Crhr2 Protein Structure

HormR

HormR: smart00008 (55 - 126)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (132 - 395)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (134 - 159)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (168 - 190)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (204 - 231)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (243 - 263)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (280 - 309)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (323 - 350)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (357 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

corticotropin-releasing factor receptor 2

CRF-R-2

CRF-R2

CRF2

CRFR-2

CRH-R-2

CRH-R2

corticotrophin releasing hormone receptor 2

corticotropin-releasing factor receptor subtype 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 99.71% Unkown
HY-RS03171 CRHR2 Human Pre-designed siRNA Set A / Unkown
HY-RS03172 Crhr2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS03173 Crhr2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crhr2 NCBI NCBI:1395