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Crhr2 - corticotropin releasing hormone receptor 2 Gene

Also Known as Crf2r; CRF-R 2; CRH-R 2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64680

About Crhr2

Primary_assembly 4: 84,224,002-84,265,904 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 203 orthologues, 42 paralogues and is associated with 23 phenotypes. Biased expression in Muscle (RPKM 8.2), Heart (RPKM 5.4) and 5 other tissues.

Summary

Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crhr2 Products (1)

mRNA	Protein	Name
NM_022714.2	NP_073205.2	corticotropin-releasing factor receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables corticotropin-releasing hormone receptor activity	IDA IDA: Inferred from direct assay	12942143	RGD
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	19334530	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	17194738	RGD
involved in catecholamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	17194738	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	21106875	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	16820012	RGD
involved in epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20551459	RGD
involved in gastric motility	IMP IMP: Inferred from mutant phenotype	16012930	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	20002962	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	17004937	RGD
involved in negative regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	19439178	RGD
involved in negative regulation of defecation	IMP IMP: Inferred from mutant phenotype	21277852	RGD
involved in negative regulation of epinephrine secretion	IMP IMP: Inferred from mutant phenotype	17194738	RGD
involved in negative regulation of feeding behavior	IDA IDA: Inferred from direct assay	17050037	RGD
involved in negative regulation of follicle-stimulating hormone secretion	IMP IMP: Inferred from mutant phenotype	19193717	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19193717	RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	17360501	RGD
involved in negative regulation of luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	19193717	RGD
involved in negative regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	17194738	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19439178	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	16005543	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	19211730	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	20060787	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	20682782	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	16005543	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19193717	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	20060787	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19211730	RGD
involved in positive regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	20655906	RGD
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	19211730	RGD
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21277852	RGD
involved in skeletal muscle tissue growth	IDA IDA: Inferred from direct assay	21235761	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	16820012	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	21481539	RGD
located in cell body fiber	IDA IDA: Inferred from direct assay	21277852	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16820012	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21277852	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	21453754	RGD
located in varicosity	IDA IDA: Inferred from direct assay	21481539	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crhr2 Protein Structure

HormR

7tmB1_CRF-R2

0
100
200
300
400
431 a.a.

Protein Preferred Names	Protein Names
corticotropin-releasing factor receptor 2	CRF-R-2 CRF-R2 CRF2 CRFR-2 CRH-R-2 CRH-R2 corticotrophin releasing hormone receptor 2 corticotropin-releasing factor receptor subtype 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3684A	[DPro5] Corticotropin Releasing Factor, human, rat TFA	Agonist	98.71%	Unkown
HY-RS03171	CRHR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03172	Crhr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03173	Crhr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crhr2	NCBI	NCBI:1395