Suv39h2 - suppressor of variegation 3-9 2 Gene

Also Known as KMT1B; D2Ertd544e; 4930507K23Rik; D030054H19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64707

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone-lysine N-methyltransferase activity. Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within histone H3-K9 methylation and male meiotic nuclear division. Located in heterochromatin and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and limb. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Suv39h2 Products (1)

mRNA Protein Name
NM_022724.4 NP_073561.2 histone-lysine N-methyltransferase SUV39H2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
11094092 MGI
enables histone H3 methyltransferase activity IDA
IDA: Inferred from direct assay
10949293 MGI
enables histone H3K9 methyltransferase activity IGI
IGI: Inferred from genetic interaction
15788566 MGI
enables histone H3K9me2 methyltransferase activity IGI
IGI: Inferred from genetic interaction
23451023 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24413057 MGI
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
11094092 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24413057 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
24413057 MGI
involved in male meiotic nuclear division IEP
IEP: Inferred from expression pattern
11094092 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24413057 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
24413057 MGI
Cellular Component GO Annotation Evidence References Source
located in heterochromatin IDA
IDA: Inferred from direct assay
11094092 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21402781 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SUV39H2

  • H3-K9-HMTase 2

  • Suv39h histone methyltransferase

  • histone H3-K9 methyltransferase 2

  • su(var)3-9 homolog 2

  • suppressor of variegation 3-9 homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122181 OTS186935 Inhibitor 99.69% Unkown
HY-122181B OTS186935 hydrochloride Inhibitor 99.58% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-122182 OTS193320 98.12% Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-13689G Go 6983 (GMP) / Unkown
HY-RS14052 SUV39H2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18319 Suv39h2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24797 Suv39h2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Suv39h2 NCBI NCBI:79723