Dock7 - dedicator of cytokinesis 7 Gene

Also Known as Gm430; 3110056M06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67299

Summary

Enables small GTPase binding activity. Involved in interkinetic nuclear migration; negative regulation of cold-induced thermogenesis; and regulation of neurogenesis. Acts upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be located in cell projection. Predicted to be part of COP9 signalosome. Is expressed in several structures, including alimentary system; central nervous system; lung; placenta; and sensory organ. Used to study platelet storage pool deficiency. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7). [provided by Alliance of Genome Resources, Apr 2022]

Dock7 Products (8)

mRNA Protein Name
NM_001290636.1 NP_001277565.1 dedicator of cytokinesis protein 7 isoform 1
NM_001369285.1 NP_001356214.1 dedicator of cytokinesis protein 7 isoform 3
NM_001369286.1 NP_001356215.1 dedicator of cytokinesis protein 7 isoform 4
NM_026082.5 NP_080358.3 dedicator of cytokinesis protein 7 isoform 2
NM_001290636.1 NP_001277565.1 dedicator of cytokinesis protein 7 isoform 1
NM_001369285.1 NP_001356214.1 dedicator of cytokinesis protein 7 isoform 3
NM_001369286.1 NP_001356215.1 dedicator of cytokinesis protein 7 isoform 4
NM_026082.5 NP_080358.3 dedicator of cytokinesis protein 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19129230 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
16982419 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
involved in interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
22842144 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23553822 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
involved in postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
21041412 MGI
involved in postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
21041412 MGI
involved in regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
22842144 MGI
Cellular Component GO Annotation Evidence References Source
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
21041412 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
21041412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 7

  • protein moonlight

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03929 DOCK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21558 Dock7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28076 Dock7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock7 NCBI NCBI:85440