Trpm4 - transient receptor potential cation channel, subfamily M, member 4 Gene

Also Known as LTRPC4; TRPM4B; LTrpC-4; 1110030C19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68667

Summary

Enables ATP binding activity; calcium activated cation channel activity; and Calcium Channel activity. Involved in several processes, including cellular response to ATP; dendritic cell chemotaxis; and protein homotetramerization. Acts upstream of or within calcium ion transport. Located in plasma membrane. Is spanning component of plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpm4 Products (1)

mRNA Protein Name
NM_175130.4 NP_780339.2 transient receptor potential cation channel subfamily M member 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
29211714 MGI
enables calcium channel activity IDA
IDA: Inferred from direct assay
12893253 MGI
enables calcium-activated cation channel activity IDA
IDA: Inferred from direct assay
17188667 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
12893253 MGI
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
29211714 MGI
involved in dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
18758465 MGI
involved in inorganic cation transmembrane transport IDA
IDA: Inferred from direct assay
29211714 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
29211714 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12893253 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 4

  • calcium-activated non-selective cation channel 1

  • long transient receptor potential channel 4

  • transient receptor potential ion channel melastatin subgroup member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128172 TRPM4-IN-2 Inhibitor 99.17% Unkown
HY-108457 9-Phenanthrol Inhibitor 99.61% Unkown
HY-153468 ErSO-TFPy Activator 99.33% Unkown
HY-183268 TRPM4-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm4 NCBI NCBI:54795