TLCD2 - TLC domain containing 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 727910

About TLCD2

This gene has 1 transcript (splice variant), 1 gene allele, 186 orthologues and 5 paralogues. Broad expression in fat (RPKM 9.2), colon (RPKM 5.9) and 17 other tissues.

Summary

Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TLCD2 Products (1)

mRNA Protein Name
NM_001164407.2 NP_001157879.1 TLC domain-containing protein 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in membrane assembly IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in plasma membrane organization IMP
IMP: Inferred from mutant phenotype
30509349 GOA
involved in regulation of membrane lipid distribution IMP
IMP: Inferred from mutant phenotype
30509349 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
30509349 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLCD2 Protein Structure

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (39 - 216)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

TLC domain-containing protein 2

Related Diseases

Diseases Alias
Chromosome 17p13.3, Centromeric, Duplication Syndrome

  • Chromosome 17p13.3 Duplication Syndrome

  • 17p13.3 Duplication Syndrome

  • 17p13.3 Microduplication Syndrome

  • Trisomy 17p13.3

  • Chromosome 17p13.3 Centromeric Duplication Syndrome

  • Dup(17)(P13.3)
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14562 TLCD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TLCD2 VGNC VGNC:103712
Felis catus TLCD2 VGNC VGNC:66207
Mus musculus TLCD2 MGD MGI:1917141
Bos taurus TLCD2 VGNC VGNC:35888
Macaca mulatta TLCD2 VGNC VGNC:104666
Rattus norvegicus TLCD2 RGD RGD:1562631
Others TLCD2 NCBI