UGDH - UDP-glucose 6-dehydrogenase Gene

Also Known as GDH; UGD; DEE84; EIEE84; UDPGDH; UDP-GlcDH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7358

About UGDH

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,498,755-39,527,439 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and is associated with 1 phenotype. Broad expression in colon (RPKM 31.0), liver (RPKM 26.9) and 23 other tissues.

Summary

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and Cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UGDH Products (3)

mRNA	Protein	Name
NM_001184700.2	NP_001171629.1	UDP-glucose 6-dehydrogenase isoform 2
NM_001184701.2	NP_001171630.1	UDP-glucose 6-dehydrogenase isoform 3
NM_003359.4	NP_003350.1	UDP-glucose 6-dehydrogenase isoform 1

UGDH Protein Structure

UDPG_MGDP_dh_N

UDPG_MGDP_dh

UDPG_MGDP_dh_C

0
100
200
300
400
494 a.a.

Protein Preferred Names	Protein Names
UDP-glucose 6-dehydrogenase	UDP-Glc dehydrogenase

UGDH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UGDH	O60701	TNPO1	Homo sapiens	Q92973	Anti Tag CoIP	35271311
Intra	UGDH	O60701	AK5	Homo sapiens	Q9Y6K8	Y2H Pooling	16169070
Intra	UGDH	O60701	UGDH	Homo sapiens	O60701	Y2H Array	25416956
Intra	UGDH	O60701	RAD51	Homo sapiens	Q06609	Y2H Array	21988832
Intra	UGDH	O60701	UGDH	Homo sapiens	O60701	GMS	32001716
Intra	UGDH	O60701	q5nge3_fratt	Francisella tularensis subsp. tularensis	Q5NGE3	Y2H Pooling	26714771
Intra	UGDH	O60701	ITGB1BP2	Homo sapiens	Q9UKP3	Y2H Fragment Pooling	23414517

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 84	DEE84 Jamuar Syndrome Eiee84 Developmental And Epileptic Encephalopathy, 84 Epileptic Encephalopathy, Early Ifantile, 84 Early Infantile Epileptic Encephalopathy 84 Epileptic Encephalopathy, Early Infantile, 84 Encephalopathy, Epileptic, Early Infantile, Type 84
Galactosemia I	Galactosemia Galt Deficiency Classic Galactosemia Galactose-1-Phosphate Uridylyltransferase Deficiency Galactose-1-Phosphate Uridyltransferase Deficiency GALAC1 Galactosemia, Classic Galactosemia Type 1 Galactosemias Classical Galactosemia Galactosaemia Galactose Intolerance Epimerase Deficiency Galactosemia Galactokinase Deficiency Disease Galactose Epimerase Deficiency Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease Gale Deficiency Galk Deficiency Udp-Galactose-4-Epimerase Deficiency Disease Utp Hexose-1-Phosphate Uridylyltransferase Deficiency Galactosemia 1 Galactosemia, Duarte Variant Deficiency Of Galactokinase Udpglucose 4-Epimerase Deficiency Disease Classical Galactosaemia Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency Classic Galactosaemia Deficiency Of Hexose-1-Phosphate Uridylyltransferase Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase Deficiency Of Galactose-1-Phosphate Uridylyltransferase Galactose-1-Phosphate Uridyl Transferase Deficiency Transferase Deficiency Galactosemia Deficiency Of Uridyl Transferase Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Spastic Paraplegia 76, Autosomal Recessive	SPG76 Autosomal Recessive Spastic Paraplegia Type 76 Hereditary Spastic Paraplegia 76 Autosomal Recessive Spastic Paraplegia 76 Paraplegia, Spastic, Autosomal Recessive, Type 76
Galactosemia Iii	Galactose Epimerase Deficiency Gale Deficiency Udp-Galactose-4-Epimerase Deficiency Epimerase Deficiency Galactosemia Galactosemia Type 3 Gale-D Uridine Diphosphate Galactose-4-Epimerase Deficiency GALAC3 Galactosemia 3 Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency Galactosemia Type Iii Udp-Galactose-4'-Epimerase Deficiency Generalized Galactose Epimerase Deficiency Generalized Gale Deficiency Generalized Gale-D Generalized Udp-Galactose-4-Epimerase Deficiency Generalized Epimerase Deficiency Galactosemia Erythrocyte Galactose Epimerase Deficiency Erythrocyte Gale Deficiency Erythrocyte Gale-D Erythrocyte Udp-Galactose-4-Epimerase Deficiency Erythrocyte Epimerase Deficiency Galactosemia Galactosemias Classical Galactosemia Udpglucose 4-Epimerase Deficiency Disease
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70020	UDP-Glc dehydrogenase (UGDH)		/	Unkown
HY-RS15422	UGDH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19969	Ugdh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26472	Ugdh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UGDH	MGD	MGI:1306785
Rattus norvegicus	UGDH	RGD	RGD:621879
Macaca mulatta	UGDH	VGNC	VGNC:78711
Felis catus	UGDH	VGNC	VGNC:66805
Bos taurus	UGDH	VGNC	VGNC:36648
Canis familiaris	UGDH	VGNC	VGNC:48117
Others	UGDH	NCBI