Kdm5b - lysine (K)-specific demethylase 5B Gene

Also Known as PUT1; Plu1; PLU-1; Rb-Bp2; Jarid1b; RBBP2H1A; mKIAA4034; D1Ertd202e; 2010009J12Rik; 2210016I17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75605

Summary

This gene encodes a lysine-specific Histone Demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain Cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]

Kdm5b Products (1)

mRNA Protein Name
NM_152895.2 NP_690855.2 lysine-specific demethylase 5B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 demethylase activity IDA
IDA: Inferred from direct assay
17320160 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21448134 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
24802759 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: Inferred from mutant phenotype
24802759 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21960634 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
24802759 MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
24802759 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
24802759 MGI
acts upstream of or within regulation of estradiol secretion IMP
IMP: Inferred from mutant phenotype
24802759 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
24802759 MGI
acts upstream of or within uterus morphogenesis IMP
IMP: Inferred from mutant phenotype
24802759 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 5B

  • [histone H3]-trimethyl-L-lysine(4) demethylase 5B

  • histone demethylase JARID1B

  • jumonji, AT rich interactive domain 1B (Rbp2 like)

  • jumonji/ARID domain-containing protein 1B

  • putative DNA/chromatin binding motif 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-102047B KDOAM-25 citrate Inhibitor 98.56% Unkown
HY-100744 AS8351 Inhibitor 99.88% Unkown
HY-116761 GSK467 Inhibitor 99.34% Unkown
HY-151483 TK-129 Inhibitor ≥98.0% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.64% Unkown
HY-119397A KDM5-C49 hydrochloride Inhibitor 98.22% Unkown
HY-149091 KDM5B-IN-4 Inhibitor 99.68% Unkown
HY-101451 PBIT Inhibitor 99.13% Unkown
HY-158432 GT-653 Degrader 99.84% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-RS07219 KDM5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-128343 KDM4-IN-2 Inhibitor 98.29% Unkown
HY-119397 KDM5-C49 Inhibitor / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-146670 KDM5B-IN-3 Inhibitor / Unkown
HY-158433 KDM5B ligand 2 / Unkown
HY-175036 YTHu78 / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS16636 Kdm5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23071 Kdm5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm5b NCBI NCBI:10765