Brpf1 - bromodomain and PHD finger containing, 1 Gene

Also Known as Brpf2; 4833438B11Rik; 4930540D11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78783

About Brpf1

Chromosome 6: 113,284,098-113,301,821 forward strand.GRCm39:CM000999.3

This gene has 10 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 14 phenotypes. Ubiquitous expression in thymus adult (RPKM 16.2), CNS E11.5 (RPKM 12.8) and 28 other tissues.

Summary

Predicted to enable acetyltransferase activator activity and histone binding activity. Involved in histone H3-K23 acetylation. Acts upstream of or within common myeloid progenitor cell proliferation; regulation of fibroblast proliferation; and tube morphogenesis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of MOZ/MORF Histone Acetyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study syndromic intellectual disability. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Brpf1 Products (4)

mRNA Protein Name
NM_001282127.1 NP_001269056.1 peregrin isoform 3
NM_001282126.1 NP_001269055.1 peregrin isoform 1
NM_001282128.1 NP_001269057.1 peregrin isoform 4
NM_030178.2 NP_084454.1 peregrin isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
27939640 MGI
acts upstream of or within common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
27528195 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
27528195 MGI
acts upstream of or within regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
27528195 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
27528195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brpf1 Protein Structure

SFP1

SFP1: cl25788 (19 - 49)

COG5141

COG5141: cl34917 (172 - 655)

ePHD_BRPF1

ePHD_BRPF1: cd15701 (328 - 448)

Bromo_brd1_like

Bromo_brd1_like: cd05512 (630 - 727)

PWWP_BRPF1

PWWP_BRPF1: cd20156 (1080 - 1199)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1212 a.a.
Protein Preferred Names Protein Names

peregrin

  • bromodomain and PHD finger-containing protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107424 BAY-299 Inhibitor 99.40% Unkown
HY-130622 LT052 Inhibitor 98.02% Unkown
HY-100729 GSK9311 Inhibitor 99.33% Unkown
HY-143332 TRIM24/BRPF1-IN-2 Inhibitor 98.74% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-100729A GSK9311 hydrochloride Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / Unkown
HY-122626 BRPF1B/TRIM24-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brpf1 NCBI NCBI:7862