ERI3 - ERI1 exoribonuclease family member 3 Gene

Homo sapiens

Also known as PINT1; PRNPIP

Gene ID: 79033 | Gene type: protein coding

About ERI3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,221,070-44,355,279 (from NCBI)

This gene has 10 transcripts (splice variants), 133 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 26.0), testis (RPKM 24.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). [provided by Alliance of Genome Resources, Apr 2022]

ERI3 Products(5)

mRNA	Protein	Name
NM_001301698.2	NP_001288627.1	ERI1 exoribonuclease 3 isoform 2
NM_001301699.1	NP_001288628.1	ERI1 exoribonuclease 3 isoform 2
NM_001301700.1	NP_001288629.1	ERI1 exoribonuclease 3 isoform 3
NM_001301701.1	NP_001288630.1	ERI1 exoribonuclease 3 isoform 4
NM_024066.3	NP_076971.1	ERI1 exoribonuclease 3 isoform 1

ERI3 Protein Structure

RNase_T

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

ERI1 exoribonuclease 3

enhanced RNAi three prime mRNA exonuclease homolog 3

Related Diseases

Diseases

Alias

Kuru

Kuru, Susceptibility To	Kuru Encephalopathy
Kuru Encephalitis	Kuru Disease

Chronic Wasting Disease

Wasting Disease, Chronic

Fatal Familial Insomnia

Insomnia, Fatal Familial	FFI
Familial Fatal Insomnia	Insomnia Familial Fatal
Insomnia Fatal Familial	Insomnia, Fatal, Familial
Ffi - [Fatal Familial Insomnia]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04498	ERI3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ERI3	VGNC	VGNC:55169
Rattus norvegicus	ERI3	RGD	RGD:1595859
Mus musculus	ERI3	MGD	MGI:2153887
Felis catus	ERI3	VGNC	VGNC:80199
Macaca mulatta	ERI3	VGNC	VGNC:72288
Canis familiaris	ERI3	VGNC	VGNC:54203