Hsf1 - heat shock transcription factor 1 Gene

Rattus norvegicus

Gene ID: 79245 | Gene type: protein coding

About Hsf1

Primary_assembly 7: 108,196,056-108,223,011 forward strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 178 orthologues, 5 paralogues and is associated with 22 phenotypes. Biased expression in Muscle (RPKM 82.5), Heart (RPKM 65.9) and 9 other tissues.

Summary

Enables several functions, including STAT family protein binding activity; promoter-specific chromatin binding activity; and sequence-specific single stranded DNA binding activity. Involved in several processes, including cellular response to lipid; positive regulation of macromolecule metabolic process; and regulation of inclusion body assembly. Located in chromatin; cytoplasm; and nucleus. Used to study Parkinson's disease; muscular atrophy; and transient cerebral ischemia. Biomarker of Alzheimer's disease; Parkinson's disease; congestive heart failure; cryptorchidism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsf1 Products(1)

mRNA	Protein	Name
NM_024393.1	NP_077369.1	heat shock factor protein 1

Hsf1 Protein Structure

HSF

Vert_HS_TF

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

heat shock factor protein 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145927	NXP800	Inhibitor	99.79%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19356	Rocaglamide	Inhibitor	99.34%	Unkown
HY-100872	KRIBB11	Inhibitor	99.54%	Unkown
HY-103000	HSF1A	Activator	99.46%	Unkown
HY-N0754	Eupalinolide A	Activator	99.92%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hsf1	NCBI	NCBI:3297

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