PGBD5 - piggyBac transposable element derived 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79605

About PGBD5

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:230,314,490-230,426,332 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Biased expression in brain (RPKM 13.1), adrenal (RPKM 4.4) and 9 other tissues.

Summary

The piggyBac family of proteins, found in diverse Animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to Other transposases, or Other known protein families. [provided by RefSeq, May 2010]

PGBD5 Products (1)

mRNA Protein Name
NM_001258311.2 NP_001245240.1 piggyBac transposable element-derived protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables transposase activity IDA
IDA: Inferred from direct assay
26406119 GOA
enables transposase activity IMP
IMP: Inferred from mutant phenotype
27491780 GOA
Biological Process GO Annotation Evidence References Source
involved in non-replicative DNA transposition IMP
IMP: Inferred from mutant phenotype
26406119 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGBD5 Protein Structure

DDE_Tnp_1_7

DDE_Tnp_1_7: Transposase IS4 (52 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 455 a.a.
Protein Preferred Names Protein Names

piggyBac transposable element-derived protein 5

  • piggyBac domain related protein 5

Related Diseases

Diseases Alias
Glioblastoma Proneural Subtype
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10379 PGBD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22721 Pgbd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29235 Pgbd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PGBD5 VGNC VGNC:100033
Bos taurus PGBD5 VGNC VGNC:32784
Mus musculus PGBD5 MGD MGI:2429955
Rattus norvegicus PGBD5 RGD RGD:1310825
Canis familiaris PGBD5 VGNC VGNC:44455
Felis catus PGBD5 VGNC VGNC:64121
Others PGBD5 NCBI