ASB13 - ankyrin repeat and SOCS box containing 13 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79754

About ASB13

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,638,867-5,666,595 (from NCBI)

This gene has 5 transcripts (splice variants) and 234 orthologues. Ubiquitous expression in kidney (RPKM 21.1), small intestine (RPKM 13.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]

ASB13 Products (1)

mRNA Protein Name
NM_024701.4 NP_078977.2 ankyrin repeat and SOCS box protein 13

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB13 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (24 - 112)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (119 - 178)

Ank

Ank: Ankyrin repeat (183 - 213)

SOCS_box

SOCS_box: SOCS box (239 - 277)

  • 0
  • 100
  • 200
  • 278 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and SOCS box protein 13

  • ankyrin repeat domain-containing SOCS box protein Asb-13

ASB13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ASB13 Q8WXK3 ZMIZ2 Homo sapiens Q8NF64-2
Validated Y2H
25416956
Intra
ASB13 Q8WXK3 ZMIZ2 Homo sapiens Q8NF64-2
Y2H Array
25416956
Intra
ASB13 Q8WXK3 ZMIZ2 Homo sapiens Q8NF64-2
Y2H Prey Pooling
25416956
Intra
ASB13 Q8WXK3 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
25416956
Intra
ASB13 Q8WXK3 VAC14 Homo sapiens Q08AM6
Y2H Array
25416956
Intra
ASB13 Q8WXK3 VAC14 Homo sapiens Q08AM6
Y2H Array
29892012
Intra
ASB13 Q8WXK3 MARK3 Homo sapiens P27448
Anti Tag CoIP
16169070
Intra
ASB13 Q8WXK3 HIF1AN Homo sapiens Q9NWT6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASB13 Proteins

Cat. No. Product Name Accession Purity
HY-P7511 ASB13 Protein, Human (His) Q8WXK3-1 (M1-N278) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Body Dysmorphic Disorder

  • Dysmorphophobia

  • Body Dysmorphia

  • Dysmorphic Syndrome

  • Body Dysmorphic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01062 ASB13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18803 Asb13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25292 Asb13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ASB13 VGNC VGNC:69865
Rattus norvegicus ASB13 RGD RGD:1310387
Canis familiaris ASB13 VGNC VGNC:52211
Bos taurus ASB13 VGNC VGNC:26190
Mus musculus ASB13 MGD MGI:2145525
Felis catus ASB13 VGNC VGNC:59958
Others ASB13 NCBI