AGBL2 - AGBL carboxypeptidase 2 Gene

Also Known as CCP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79841

About AGBL2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,659,591-47,715,369 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 191 orthologues and 5 paralogues. Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues.

Summary

Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]

AGBL2 Products (1)

mRNA Protein Name
NM_024783.4 NP_079059.2 cytosolic carboxypeptidase 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21303978 GOA
Cellular Component GO Annotation Evidence References Source
located in centriole IDA
IDA: Inferred from direct assay
23085998 GOA
located in ciliary basal body IDA
IDA: Inferred from direct assay
23085998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGBL2 Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (417 - 636)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
Protein Preferred Names Protein Names

cytosolic carboxypeptidase 2

  • ATP/GTP binding protein like 2

Related Diseases

Diseases Alias
Palindromic Rheumatism

  • Hench'S Syndrome

  • Hench-Rosenberg Syndrome

  • Palindromic Rheumatism Syndrome

  • Palindromic Arthritis
Tenosynovitis

  • Inflammation Of Tendon Sheath

  • Synovitis Or Tenosynovitis
Periarthritis
3mc Syndrome

  • Craniofacial-Ulnar-Renal Syndrome

  • Malpuech Facial Clefting Syndrome

  • Oculopalatoskeletal Syndrome

  • Carnevale Syndrome

  • Michels Syndrome

  • Malpuech-Michels-Mingarelli-Carnevale Syndrome

  • Carnevale-Krajewska-Fischetto Syndrome

  • Craniosynostosis With Lid Anomalies

  • Malpuech Syndrome

  • Mingarelli Syndrome

  • Oculo-Skeletal-Abdominal Syndrome

  • Osa Syndrome

  • Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

  • Ptosis-Strabismus-Rectus Abdominis Diastasis
Crest Syndrome
Hemolytic Uremic Syndrome, Atypical 1

  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00441 AGBL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AGBL2 VGNC VGNC:99539
Mus musculus AGBL2 MGD MGI:2443254
Bos taurus AGBL2 VGNC VGNC:106635
Felis catus AGBL2 VGNC VGNC:59677
Canis familiaris AGBL2 VGNC VGNC:37696
Rattus norvegicus AGBL2 RGD RGD:1306827
Others AGBL2 NCBI