Dlat - dihydrolipoamide S-acetyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81654

Summary

Enables dihydrolipoyllysine-residue acetyltransferase activity. Involved in acetyl-CoA biosynthetic process from pyruvate and sleep. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlat Products (1)

mRNA Protein Name
NM_031025.1 NP_112287.1 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dihydrolipoyllysine-residue acetyltransferase activity IDA
IDA: Inferred from direct assay
7487891 RGD
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA biosynthetic process from pyruvate IDA
IDA: Inferred from direct assay
7487891 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
3571977 RGD
part of pyruvate dehydrogenase complex IDA
IDA: Inferred from direct assay
7487891 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

  • 70 kDa mitochondrial autoantigen of primary biliary cirrhosis

  • E2

  • PBC

  • PDC-E2

  • PDCE2

  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

  • dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

  • p

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162386 UM4118 99.95% Unkown
HY-RS03792 DLAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178914 Copper ionophore I 99.9% Unkown
HY-RS17105 Dlat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116330 Hyperforin / Unkown
HY-RS23549 Dlat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlat NCBI NCBI:1737