Cdk16 - cyclin-dependent kinase 16 Gene

Also Known as Pctk1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81741

About Cdk16

Primary_assembly X: 1,492,814-1,504,148 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 174 orthologues, 24 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 87.6), Heart (RPKM 84.3) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including regulation of Insulin secretion involved in cellular response to glucose stimulus; regulation of transcription involved in G1/S transition of mitotic cell cycle; and secretion by cell. Located in synaptic vesicle. Orthologous to human CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Apr 2022]

Cdk16 Products (2)

mRNA Protein Name
NM_001004132.2 NP_001004132.1 cyclin-dependent kinase 16
NM_031077.2 NP_112339.2 cyclin-dependent kinase 16

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
16461345 RGD
Cellular Component GO Annotation Evidence References Source
located in synaptic vesicle IDA
IDA: Inferred from direct assay
16461345 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
16461345 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk16 Protein Structure

STKc_PCTAIRE1

STKc_PCTAIRE1: cd07873 (243 - 539)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 16

  • PCTAIRE protein kinase 1

  • PCTAIRE-1 protein kinase, alternatively spliced

  • PCTAIRE-motif protein kinase 1

  • cell division protein kinase 16

  • serine/threonine-protein kinase PCTAIRE-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-148063 DB0614 99.92% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-160213 JA397 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk16 NCBI NCBI:5127