Lrp4 - LDL receptor related protein 4 Gene

Also Known as Megf7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83469

Summary

Enables Apolipoprotein binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in dendrite morphogenesis and synapse organization. Located in several cellular components, including neuronal cell body; plasma membrane raft; and postsynaptic density. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrp4 Products (1)

mRNA Protein Name
NM_031322.3 NP_112612.2 low-density lipoprotein receptor-related protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables apolipoprotein binding IPI
IPI: Inferred from physical interaction
17889837 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18957220 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
18957220 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
16819975 RGD
Biological Process GO Annotation Evidence References Source
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
17889837 RGD
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
17889837 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16819975 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16819975 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16819975 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
17889837 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
16819975 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
16819975 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 4

  • LRP-4

  • multiple epidermal growth factor-like domains 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03047 CORIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07799 LRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17975 Corin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19911 Lrp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26412 Lrp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp4 NCBI NCBI:4038