UCK1 - uridine-cytidine kinase 1 Gene

Also Known as URK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83549

About UCK1

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:131,523,801-131,531,263 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues.

Summary

This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

UCK1 Products (5)

mRNA Protein Name
NM_001135954.3 NP_001129426.1 uridine-cytidine kinase 1 isoform b
NM_001261450.3 NP_001248379.1 uridine-cytidine kinase 1 isoform c
NM_001261451.3 NP_001248380.1 uridine-cytidine kinase 1 isoform d
NM_001318519.2 NP_001305448.1 uridine-cytidine kinase 1 isoform e
NM_031432.5 NP_113620.1 uridine-cytidine kinase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytidine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26871637 GOA
enables uridine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
Biological Process GO Annotation Evidence References Source
involved in CTP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
involved in UMP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCK1 Protein Structure

PRK

PRK: Phosphoribulokinase / Uridine kinase family (25 - 218)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

uridine-cytidine kinase 1

  • cytidine monophosphokinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-78574 N-Benzoylcytidine 99.50% Unkown
HY-RS02737 CKLF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15403 UCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UCK1 VGNC VGNC:58343
Mus musculus UCK1 MGD MGI:98904
Rattus norvegicus UCK1 RGD RGD:1308313
Macaca mulatta UCK1 VGNC VGNC:78967
Felis catus UCK1 VGNC VGNC:103005
Bos taurus UCK1 VGNC VGNC:36634
Others UCK1 NCBI