Cdkn1b - cyclin-dependent kinase inhibitor 1B Gene

Also Known as p27; Kip1; CDKN4; Cdki1b; P27KIP1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83571

Summary

Enables HSP70 protein binding activity and chaperone binding activity. Involved in several processes, including regulation of cyclin-dependent protein serine/threonine kinase activity; response to estradiol; and response to glucose. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1b Products (1)

mRNA Protein Name
NM_031762.3 NP_113950.2 cyclin-dependent kinase inhibitor 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
10198213 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9675118 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10952244 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
10198213 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
28854428 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23612739 RGD
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
22584582 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28854428 RGD
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
22223646 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17006629 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
16824045 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16730872 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18496635 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15698433 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15799773 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18490856 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18496635 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18413661 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
10198213 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 1B

  • Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

  • cyclin-dependent kinase inhibitor p27

  • cyclin-dependent kinase inhibitor p27/Kip1

Cdkn1b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cdkn1b O08769 e1a_ade05 Human adenovirus C P03255
Pull Down
9675118
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161989 DZ-837 Degrader 96.04% Unkown
HY-RS19053 Cdkn1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02412 CDKN1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25543 Cdkn1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn1b NCBI NCBI:1027