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TMEM175 - transmembrane protein 175 Gene

Also Known as hTMEM175

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84286

About TMEM175

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:932,460-958,656 (from NCBI)

This gene has 22 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in spleen (RPKM 10.8), brain (RPKM 6.7) and 25 other tissues.

Summary

Enables potassium ion leak channel activity. Involved in potassium ion transmembrane transport. Located in endosome and lysosome. Is integral component of endosome membrane and integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM175 Products (7)

mRNA	Protein	Name
NM_001297423.2	NP_001284352.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297424.2	NP_001284353.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297425.2	NP_001284354.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297426.2	NP_001284355.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297427.2	NP_001284356.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297428.2	NP_001284357.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_032326.4	NP_115702.1	endosomal/lysosomal potassium channel TMEM175 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate binding	IDA IDA: Inferred from direct assay	35750034	GOA
enables potassium channel activity	IDA IDA: Inferred from direct assay	28723891	GOA
enables potassium ion leak channel activity	IDA IDA: Inferred from direct assay	26317472	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33505021	GOA
enables proton channel activity	IDA IDA: Inferred from direct assay	35333573	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lysosomal lumen pH elevation	IDA IDA: Inferred from direct assay	35333573	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	26317472	GOA
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	35333573	GOA
involved in regulation of lysosomal lumen pH	IDA IDA: Inferred from direct assay	35750034	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endosome	IDA IDA: Inferred from direct assay	26317472	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	32228865	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	35750034	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	32228865	GOA
located in lysosome	IDA IDA: Inferred from direct assay	26317472	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM175 Protein Structure

DUF1211

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
endosomal/lysosomal potassium channel TMEM175	endosomal/lysomomal potassium channel TMEM175

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 3	MGORS3 Meier-Gorlin Syndrome, Type 3
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-33878	2-PPA	Inhibitor	99.98%	Unkown
HY-161949	AP-6	Inhibitor	99.84%	Unkown
HY-162666	TMEM175 modulator 1	Modulator	98.91%	Unkown
HY-RS29457	TMEM175 Monkey Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19555	Tmem175 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181621	Tmem175 modulator 2	Modulator	/	Unkown
HY-181622	TMEM175 modulator 3	Activator	/	Unkown
HY-182768	TMEM175 modulator-4	Modulator	/	Unkown
HY-RS14683	TMEM175 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182464	DABMA	Activator	/	Unkown
HY-RS26051	Tmem175 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMEM175	VGNC	VGNC:79736
Bos taurus	TMEM175	VGNC	VGNC:35999
Felis catus	TMEM175	VGNC	VGNC:66291
Rattus norvegicus	TMEM175	RGD	RGD:1309712
Mus musculus	TMEM175	MGD	MGI:1919642
Canis familiaris	TMEM175	VGNC	VGNC:47500
Others	TMEM175	NCBI