Ackr3 - atypical chemokine receptor 3 Gene

Also Known as Rdc1; Cxcr7; Cmkor1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84348

About Ackr3

Primary_assembly 9: 90,799,686-90,811,237 forward strand.mRatBN7.2:CM026982.1

This gene has 6 transcripts (splice variants), 252 orthologues, 24 paralogues and is associated with 12 phenotypes. Biased expression in Heart (RPKM 129.4), Lung (RPKM 118.2) and 9 other tissues.

Summary

Predicted to enable chemokine binding activity; Chemokine Receptor activity; and scavenger receptor activity. Involved in positive regulation of mesenchymal stem cell migration. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human ACKR3 (atypical Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ackr3 Products (1)

mRNA Protein Name
NM_053352.2 NP_445804.1 atypical chemokine receptor 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mesenchymal stem cell migration IMP
IMP: Inferred from mutant phenotype
24924806 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ackr3 Protein Structure

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (44 - 325)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (45 - 71)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (78 - 102)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (116 - 146)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (159 - 180)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (208 - 235)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (244 - 274)

7tmA_ACKR3_CXCR7

7tmA_ACKR3_CXCR7: cd14987 (293 - 318)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 3

  • C-X-C chemokine receptor type 7

  • CXC-R7

  • CXCR-7

  • G-protein coupled receptor RDC1 homolog

  • RDC-1

  • chemokine (C-X-C motif) receptor 7

  • chemokine orphan receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10333A LIH383 TFA Agonist 99.83% Unkown
HY-123813 CCX-777 Agonist 98.47% Unkown
HY-123813A CCX-777 formic Agonist 98.01% Unkown
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159582 ACKR3 agonist 1 Agonist / Unkown
HY-161414 trans-VUF25471 Agonist / Unkown
HY-179035 TBS6b Degrader / Unkown
HY-182533 LN5972 Agonist / Unkown
HY-D2201 Fluorescent ACKR3 antagonist 1 / Unkown
HY-P10333 LIH383 Agonist / Unkown
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174787 Human ACKR3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ackr3 NCBI NCBI:57007