USP38 - ubiquitin specific peptidase 38 Gene

Also Known as HP43.8KD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84640

About USP38

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:143,184,917-143,223,874 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 7.3), colon (RPKM 5.9) and 25 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP38 Products (4)

mRNA Protein Name
NM_001290325.1 NP_001277254.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 2
NM_001290326.1 NP_001277255.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 3
NM_001410848.1 NP_001397777.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 4
NM_032557.6 NP_115946.2 ubiquitin carboxyl-terminal hydrolase 38 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
34102342 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
27692986 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
34102342 GOA
involved in protein K33-linked deubiquitination IDA
IDA: Inferred from direct assay
27692986 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
27692986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP38 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (445 - 946)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 38

  • deubiquitinating enzyme 38

USP38 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP38 Q8NB14 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
USP38 Q8NB14 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
USP38 Q8NB14 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
USP38 Q8NB14 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
USP38 Q8NB14 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
USP38 Q8NB14 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
USP38 Q8NB14 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
USP38 Q8NB14 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
USP38 Q8NB14 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
USP38 Q8NB14 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
USP38 Q8NB14 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
USP38 Q8NB14 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15549 USP38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19493 Usp38 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25987 Usp38 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP38 VGNC VGNC:48193
Macaca mulatta USP38 VGNC VGNC:79224
Felis catus USP38 VGNC VGNC:66884
Bos taurus USP38 VGNC VGNC:36727
Mus musculus USP38 MGD MGI:1922091
Rattus norvegicus USP38 RGD RGD:1311974