2. Gene
  3. ADAM7 - ADAM metallopeptidase domain 7 Gene

ADAM7 - ADAM metallopeptidase domain 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EAPI; GP83; GP-83; ADAM 7; ADAM-7

Gene ID: 8756 | Gene type: protein coding

About ADAM7

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:24,441,026-24,509,565 (from NCBI)

This gene has 4 transcripts (splice variants), 361 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

ADAM7 Products(1)

mRNA Protein Name
NM_003817.4 NP_003808.2 disintegrin and metalloproteinase domain-containing protein 7 preproprotein

ADAM7 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (28 - 156)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (199 - 394)

Disintegrin

Disintegrin: Disintegrin (411 - 485)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (488 - 604)

  • 0
  • 200
  • 400
  • 600
  • 754 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 7

a disintegrin and metalloproteinase domain 7

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00285 ADAM7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAM7 VGNC VGNC:37586
Felis catus ADAM7 VGNC VGNC:82363
Rattus norvegicus ADAM7 RGD RGD:62032
Bos taurus ADAM7 VGNC VGNC:56934
Macaca mulatta ADAM7 VGNC VGNC:69493
Mus musculus ADAM7 MGD MGI:107247