CD84 - CD84 molecule Gene

Homo sapiens

Also known as LY9B; hCD84; mCD84; SLAMF5

Gene ID: 8832 | Gene type: protein coding

About CD84

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,541,098-160,579,496 (from NCBI)

This gene has 8 transcripts (splice variants), 154 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

CD84 Products(5)

mRNA	Protein	Name
NM_001184879.2	NP_001171808.1	SLAM family member 5 isoform 1 precursor
NM_001184881.2	NP_001171810.1	SLAM family member 5 isoform 3 precursor
NM_001184882.2	NP_001171811.1	SLAM family member 5 isoform 4 precursor
NM_001330742.2	NP_001317671.1	SLAM family member 5 isoform 5 precursor
NM_003874.4	NP_003865.1	SLAM family member 5 isoform 2 precursor

CD84 Protein Structure

Ig_3

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

SLAM family member 5

CD84 antigen (leukocyte antigen)

Recombinant CD84 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72414	CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9UIB8-1 (K22-R220)	≥95%
HY-P72463	CD84/SLAMF5 Protein, Human (199a.a, HEK293, His)	Q9UIB8 (K22-R220)	≥95%
HY-P77327	CD84/SLAMF5 Protein, Human (225a.a, HEK293, His)	Q9UIB8 (M1-G225)	≥95%
HY-P78418	CD84/SLAMF5 Protein, Human (HEK293, His-Avi)	Q9UIB8 (K22-G225)	≥95%

Related Diseases

Diseases

Alias

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Selective Immunoglobulin Deficiency Disease

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Dysgammaglobulinemia

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02273	CD84 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD84	VGNC	VGNC:38978
Macaca mulatta	CD84	VGNC	VGNC:70784
Rattus norvegicus	CD84	RGD	RGD:1564553
Mus musculus	CD84	MGD	MGI:1336885
Bos taurus	CD84	VGNC	VGNC:53854
Felis catus	CD84	VGNC	VGNC:60642
Macaca fascicularis	CD84	NCBI
Others	CD84	NCBI