CD84 - CD84 molecule Gene

Also Known as LY9B; hCD84; mCD84; SLAMF5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8832

About CD84

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,541,098-160,579,496 (from NCBI)

This gene has 8 transcripts (splice variants), 154 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 11.0) and 19 other tissues.

Summary

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

CD84 Products (5)

mRNA Protein Name
NM_001184879.2 NP_001171808.1 SLAM family member 5 isoform 1 precursor
NM_001184881.2 NP_001171810.1 SLAM family member 5 isoform 3 precursor
NM_001184882.2 NP_001171811.1 SLAM family member 5 isoform 4 precursor
NM_001330742.2 NP_001317671.1 SLAM family member 5 isoform 5 precursor
NM_003874.4 NP_003865.1 SLAM family member 5 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17563375 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12928397 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: Inferred from direct assay
22068234 GOA
involved in negative regulation of interleukin-18 production IDA
IDA: Inferred from direct assay
22068234 GOA
involved in negative regulation of mast cell activation IDA
IDA: Inferred from direct assay
22068234 GOA
involved in negative regulation of mast cell degranulation IDA
IDA: Inferred from direct assay
22068234 GOA
involved in regulation of store-operated calcium entry IDA
IDA: Inferred from direct assay
22068234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD84 Protein Structure

Ig_3

Ig_3: Immunoglobulin domain (134 - 197)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

SLAM family member 5

  • CD84 antigen (leukocyte antigen)

CD84 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
GMS
17563375
Intra
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
X-Ray Diffraction
17563375
Intra
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
Solution Sedimentation
17563375
Intra
CD84 Q9UIB8 SH2D1A Homo sapiens O60880
CoIP
12928397
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD84 Proteins

Cat. No. Product Name Accession Purity
HY-P72414 CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi) Q9UIB8-1 (K22-R220) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72463 CD84/SLAMF5 Protein, Human (HEK293, His) Q9UIB8-1 (K22-R220) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78418 CD84/SLAMF5 Protein, Human (HEK293, His-Avi) Q9UIB8-1 (K22-G225) ≥ 95%, as determined by Bis-Tris PAGE.

CD84 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85010 CD84 Antibody (YA4702) ELISA, FC Human

Related Diseases

Diseases Alias
Multisystem Inflammatory Syndrome In Children

  • Mis-C

  • Multisystem Inflammatory Disorder In Children And Adolescents

  • Paediatric Inflammatory Multisystemic Syndrome

  • Mic
Selective Immunoglobulin Deficiency Disease
Lymphoproliferative Syndrome

  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To
Dysgammaglobulinemia
Lymphoproliferative Syndrome, X-Linked, 1

  • Lymphomatoid Papulosis

  • Duncan Disease

  • Purtilo Syndrome

  • X-Linked Lymphoproliferative Syndrome

  • Xlp

  • X-Linked Lymphoproliferative Disease

  • XLP1

  • Lyp

  • Lymphoproliferative Disease, X-Linked

  • Xlpd

  • X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

  • Ebv Infection, Severe, Susceptibility To

  • Ebvs

  • Immunodeficiency 5

  • Imd5

  • X-Linked Lymphoproliferative Syndrome 1

  • Epstein-Barr Virus Infection, Familial Fatal

  • Ebv Infection, Severe

  • Infectious Mononucleosis, Severe

  • Infectious Mononucleosis, Severe, Susceptibility To

  • Immunodeficiency, X-Linked Progressive Combined Variable

  • Epstein Barr Virus Infection, Familial Fatal

  • X-Linked Progressive Combined Variable Immunodeficiency 5

  • Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

  • Familial Fatal Epstein-Barr Infection

  • Severe Susceptibility To Ebv Infection

  • Severe Susceptibility To Infectious Mononucleosis

  • Sap Deficiency

  • Sh2d1a/Slam-Associated Protein Deficiency

  • X-Linked Lymphoproliferative Syndrome Type 1

  • X-Linked Progressive Combined Variable Immunodeficiency

  • Lymphoproliferative Syndrome, X-Linked

  • Sap

  • X-Linked Lymphoproliferative Disorder
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02273 CD84 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17801 Cd84 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24269 Cd84 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992214 Anti-CD84 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CD84 VGNC VGNC:38978
Macaca mulatta CD84 VGNC VGNC:70784
Rattus norvegicus CD84 RGD RGD:1564553
Mus musculus CD84 MGD MGI:1336885
Bos taurus CD84 VGNC VGNC:53854
Felis catus CD84 VGNC VGNC:60642
Others CD84 NCBI