Socs3 - suppressor of cytokine signaling 3 Gene

Also Known as Cish3; Ssi-3; Socs-3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89829

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and phosphotyrosine residue binding activity. Involved in several processes, including receptor signaling pathway via JAK-STAT; response to estradiol; and response to steroid hormone. Located in cytoplasm. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Apr 2022]

Socs3 Products (1)

mRNA Protein Name
NM_053565.1 NP_446017.1 suppressor of cytokine signaling 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
11867182 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
12239110 RGD
involved in cellular response to thyrotropin-releasing hormone IEP
IEP: Inferred from expression pattern
10707961 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
10707961 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12239110 RGD
involved in response to bacterium IEP
IEP: Inferred from expression pattern
17405912 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18424750 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18325991 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
12163036 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
14751512 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
10998044 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
11133009 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16125475 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15192048 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18424750 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12239110 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12107179 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
18325991 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17394460 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of cytokine signaling 3

  • cytokine inducible SH2-containing protein 3

  • cytokine-inducible SH2 protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0444 Rubiadin 99.20% Unkown
HY-155335 FPR2 agonist 3 Agonist 99.39% Unkown
HY-RS16260 Socs3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117511 HJC0123 99.06% Unkown
HY-169908 STAT3-IN-37 Inhibitor / Unkown
HY-RS13554 SOCS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124595 MPT0B098 Inhibitor / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-RS23359 Socs3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5) Inhibitor 98.666% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Socs3 NCBI NCBI:9021