DIRAS3 - DIRAS family GTPase 3 Gene

Homo sapiens

Also known as ARHI; NOEY2

Gene ID: 9077 | Gene type: protein coding

About DIRAS3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,045,962-68,050,627 (from NCBI)

This gene has 4 transcripts (splice variants), 50 orthologues and 35 paralogues. Biased expression in ovary (RPKM 20.7), adrenal (RPKM 6.9) and 11 other tissues.

Summary

This gene encodes a member of the Ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role Autophagy in certain Cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

DIRAS3 Products(1)

mRNA	Protein	Name
NM_004675.5	NP_004666.1	GTP-binding protein Di-Ras3 precursor

DIRAS3 Protein Structure

Ras

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

GTP-binding protein Di-Ras3

DIRAS family, GTP-binding RAS-like 3

Recombinant DIRAS3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75500	ARHI Protein, Human (HEK293, Fc)	O95661 (M1-K225)	≥95%

Related Diseases

Diseases

Alias

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03777	DIRAS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DIRAS3	VGNC	VGNC:28071
Macaca mulatta	DIRAS3	VGNC	VGNC:71827
Rattus norvegicus	DIRAS3	RGD	RGD:1565168
Others	DIRAS3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.