CERS5 - ceramide synthase 5 Gene

Also Known as Trh4; LASS5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91012

About CERS5

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,129,289-50,167,369 (from NCBI)

This gene has 28 transcripts (splice variants), 255 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 6.0), placenta (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CERS5 Products (7)

mRNA Protein Name
NM_001281731.2 NP_001268660.1 ceramide synthase 5 isoform 2
NM_001331069.3 NP_001317998.1 ceramide synthase 5 isoform 3
NM_001331070.3 NP_001317999.1 ceramide synthase 5 isoform 4
NM_001331071.3 NP_001318000.1 ceramide synthase 5 isoform 5
NM_001331072.3 NP_001318001.1 ceramide synthase 5 isoform 6
NM_001331073.3 NP_001318002.1 ceramide synthase 5 isoform 7
NM_147190.5 NP_671723.1 ceramide synthase 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
16951403 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
16951403 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERS5 Protein Structure

Homeobox

Homeobox: Homeobox domain (90 - 134)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (140 - 333)

  • 0
  • 100
  • 200
  • 300
  • 392 a.a.
Protein Preferred Names Protein Names

ceramide synthase 5

  • LAG1 homolog, ceramide synthase 5

Related Diseases

Diseases Alias
Hereditary Sensory And Autonomic Neuropathy Type 1

  • Hereditary Sensory And Autonomic Neuropathy Type I

  • Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

  • Hsan1e

  • Hsan1

  • Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

  • Hsn1e

  • Hsnie

  • Hereditary Sensory Neuropathy Type Ie

  • Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

  • Hereditary Sensory And Autonomic Neuropathy Type Ie

  • Hereditary Sensory And Autonomic Neuropathy Type 1e

  • Hereditary Sensory Neuropathy With Hearing Loss And Dementia

  • Dnmt1-Complex Disorder

  • Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

  • Hsn Ie

  • Hereditary Sensory Autonomic Neuropathy, Type 1

  • Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146942S CER5-2’S-d9 / Unkown
HY-RS02540 CERS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02541 CERS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146909S CER5-2’R-d9 99.0% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CERS5 MGD MGI:1919199
Canis familiaris CERS5 VGNC VGNC:39151
Felis catus CERS5 VGNC VGNC:60795
Rattus norvegicus CERS5 RGD RGD:1311597
Macaca mulatta CERS5 VGNC VGNC:71078
Bos taurus CERS5 VGNC VGNC:27227
Others CERS5 NCBI