SLC28A2 - solute carrier family 28 member 2 Gene

Also Known as CNT2; HCNT2; SPNT1; HsT17153

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9153

About SLC28A2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,252,234-45,277,846 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 43.4), duodenum (RPKM 31.3) and 4 other tissues.

Summary

Enables neurotransmitter transmembrane transporter activity and nucleoside transmembrane transporter activity. Involved in several processes, including nucleoside transport; purine nucleobase transmembrane transport; and pyrimidine-containing compound transmembrane transport. Predicted to be located in membrane. Predicted to be part of brush border membrane; coated vesicle; and vesicle membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC28A2 Products (1)

mRNA Protein Name
NM_004212.4 NP_004203.2 sodium/nucleoside cotransporter 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neurotransmitter transmembrane transporter activity IDA
IDA: Inferred from direct assay
10087507 GOA
enables nucleoside:sodium symporter activity IDA
IDA: Inferred from direct assay
10087507 GOA
enables purine nucleobase transmembrane transporter activity IDA
IDA: Inferred from direct assay
22492015 GOA
enables purine nucleoside transmembrane transporter activity IDA
IDA: Inferred from direct assay
10087507 GOA
enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
IDA: Inferred from direct assay
10087507 GOA
enables uridine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10087507 GOA
Biological Process GO Annotation Evidence References Source
involved in adenosine transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in inosine transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in neurotransmitter transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in nucleoside transmembrane transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in purine nucleobase transmembrane transport IDA
IDA: Inferred from direct assay
22492015 GOA
involved in purine nucleoside transmembrane transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in pyrimidine-containing compound transmembrane transport IDA
IDA: Inferred from direct assay
10087507 GOA
involved in uridine transmembrane transport IDA
IDA: Inferred from direct assay
10087507 GOA
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
35307651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC28A2 Protein Structure

Nucleos_tra2_N

Nucleos_tra2_N: Na+ dependent nucleoside transporter N-terminus (179 - 251)

Gate

Gate: Nucleoside recognition (259 - 354)

Nucleos_tra2_C

Nucleos_tra2_C: Na+ dependent nucleoside transporter C-terminus (362 - 585)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

sodium/nucleoside cotransporter 2

  • CNT 2

Related Diseases

Diseases Alias
Hyperuricemia

  • Blood Urate Raized

  • Uricacidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13151 SLC28A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC28A2 VGNC VGNC:77445
Rattus norvegicus SLC28A2 RGD RGD:61840
Bos taurus SLC28A2 VGNC VGNC:34792
Others SLC28A2 NCBI