CD5 - CD5 molecule Gene
Also Known as T1; LEU1
Species: Homo sapiens
About CD5
This gene has 2 transcripts (splice variants), 405 orthologues and 15 paralogues. Biased expression in lymph node (RPKM 19.1), appendix (RPKM 11.9) and 10 other tissues.
Summary
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I Transmembrane Glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
CD5 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001346456.2 | NP_001333385.1 | T-cell surface glycoprotein CD5 isoform 2 |
| NM_014207.4 | NP_055022.2 | T-cell surface glycoprotein CD5 isoform 1 precursor |
CD5 Protein Structure
SRCR: Scavenger receptor cysteine-rich domain (39 - 132)
SRCR: Scavenger receptor cysteine-rich domain (279 - 368)
- 0
- 100
- 200
- 300
- 400
- 495 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-cell surface glycoprotein CD5 |
|
Recombinant CD5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72920 | CD5 Protein, Human (HEK293, His) | P06127 (R25-P372) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74286 | CD5 Protein, Human (HEK293, Fc) | P06127 (R25-P372) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P74287 | CD5 Protein, Human (Biotinylated , HEK293, His-Avi) | P06127 (R25-P372) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78093 | CD5 Protein, Human (Biotinylated, HEK293, Fc-Avi) | P06127 (R25-N371) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78413 | CD5 Protein, Human (HEK293, Fc-Avi) | P06127 (R25-N371) | ≥ 95%, as determined by Bis-Tris PAGE. |
CD5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81659 | CD5 Antibody (YA1404) | WB, IHC-P, ICC/IF, IP | Human |
| HY-P83720 | CD5 Antibody (YA3453) | WB, IHC-P, FC, ELISA | Human, Mouse |
| HY-P83720A | CD5 Antibody (YA3453)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse |
| HY-P85896 | CD5 Antibody (YA5588) | IHC-P, WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Thymic Carcinoma |
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| Prolymphocytic Leukemia |
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| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma |
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| Gastrointestinal Lymphoma |
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| B-Cell Prolymphocytic Leukemia |
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
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| Epithelial Malignant Thymoma |
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| Dendritic Cell Thymoma |
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| Lymphoepithelioma-Like Thymic Carcinoma |
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| Hairy Cell Leukemia |
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| Thymoma |
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| Richter'S Syndrome |
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| Tracheal Lymphoma |
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| Combined Thymoma |
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| Leukemia, Chronic Lymphocytic 2 |
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| Hepatosplenic T-Cell Lymphoma |
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| Mediastinal Cancer |
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| Thymus Large Cell Carcinoma |
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| Choroid Spindle Cell Melanoma |
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| Spleen Cancer |
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| B-Cell Lymphoma |
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| Cryoglobulinemia |
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| Lymphoma, Mucosa-Associated Lymphoid Type |
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| Lymphoplasmacytic Lymphoma |
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| Splenic Marginal Zone Lymphoma |
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| Thymus Adenocarcinoma |
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| Colon Lymphoma |
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| Lung Lymphoma |
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| Lymphoproliferative Syndrome |
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| Spindle Cell Thymoma |
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| Marginal Zone B-Cell Lymphoma |
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| Ureteral Lymphoma |
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| Nodal Marginal Zone Lymphoma |
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| Breast Lymphoma |
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| Leukemia, Chronic Lymphocytic |
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| Cryoglobulinemia, Familial Mixed |
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| Lymphoma, Non-Hodgkin, Familial |
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| Peripheral T-Cell Lymphoma |
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| Plasmacytoma |
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| Composite Lymphoma |
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| Thymus Clear Cell Carcinoma |
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| Thyroid Lymphoma |
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| Primary Cutaneous Gamma-Delta T-Cell Lymphoma |
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| Gallbladder Lymphoma |
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| Lymphoma |
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| Appendix Lymphoma |
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| B-Cell Expansion With Nfkb And T-Cell Anergy |
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| Thymus Gland Disease |
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| Ectopic Thymus |
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| Follicular Lymphoma |
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| Bladder Lymphoma |
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| Mature T-Cell And Nk-Cell Lymphoma |
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| Gastric Lymphoma |
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| Aggressive Nk-Cell Leukemia |
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| Thymus Cancer |
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| Bone Lymphoma |
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| Small Intestine Lymphoma |
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| Prostate Lymphoma |
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| Thymus Basaloid Carcinoma |
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| Parapsoriasis |
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| T-Cell Prolymphocytic Leukemia |
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| Chest Wall Lymphoma |
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| Retroperitoneal Lymphoma |
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| Follicular Mucinosis |
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| Type C Thymoma |
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| Encapsulated Thymoma |
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| T-Cell Adult Acute Lymphocytic Leukemia |
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| Plasma Protein Metabolism Disease |
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| Splenic Disease |
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| Sternum Cancer |
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| Sternum Lymphoma |
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| Rectum Lymphoma |
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| Liver Lymphoma |
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| Mediastinum Sarcoma |
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| Breast Implant-Associated Anaplastic Large Cell Lymphoma |
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| Mantle Cell Lymphoma |
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| Eye Lymphoma |
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| Ovarian Lymphoma |
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| Angioimmunoblastic T-Cell Lymphoma |
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| Lethal Midline Granuloma |
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| Anemia, Autoimmune Hemolytic |
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| Central Nervous System Hematologic Cancer |
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| T-Cell Large Granular Lymphocyte Leukemia |
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| Epiglottis Neoplasm |
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| Intraocular Lymphoma |
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| Central Nervous System Lymphoma |
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| Childhood Lymphoma |
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| Spindle Epithelial Tumor With Thymus-Like Differentiation Tumor |
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| Adult Lymphoma |
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| Orbital Disease |
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| Spongiotic Dermatitis |
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| Papillary Thymic Adenocarcinoma |
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| Extramedullary Plasmacytoma |
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| Chromosome 13q14 Deletion Syndrome |
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| Splenic Infarction |
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| Autoimmune Disease Of Blood |
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| Mature B-Cell Neoplasm |
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| Adult Acute Lymphocytic Leukemia |
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| Adult T-Cell Leukemia/Lymphoma |
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| Pleural Empyema |
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| Lymphatic System Cancer |
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| Orofaciodigital Syndrome Viii |
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| Waldenstroem'S Macroglobulinemia |
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| Lymphatic System Disease |
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| Sezary'S Disease |
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| Leukocyte Disease |
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| Sclerosing Hepatic Carcinoma |
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| Rheumatoid Arthritis |
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| Thyrotoxic Exophthalmos |
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| Autoimmune Disease |
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| Acute Biphenotypic Leukemia |
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| Endocrine Exophthalmos |
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| Hypersensitivity Reaction Type Iv Disease |
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| Diffuse Large B-Cell Lymphoma |
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| Pancytopenia |
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| Blood Platelet Disease |
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| Leukemia, Acute Lymphoblastic |
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| Dermatitis, Atopic, 5 |
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| Paranasal Sinus Lymphoma |
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| Immune Deficiency Disease |
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| Disseminated Eosinophilic Collagen Disease |
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| Thymus Sarcomatoid Carcinoma |
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| T-Cell Acute Lymphoblastic Leukemia |
|
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| Deficiency Anemia |
|
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| Celiac Disease 1 |
|
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| Leukemia, Acute Myeloid |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CD5 | MGD | MGI:88340 |
| Bos taurus | CD5 | VGNC | VGNC:27037 |
| Felis catus | CD5 | VGNC | VGNC:60632 |
| Rattus norvegicus | CD5 | RGD | RGD:2309 |
| Macaca mulatta | CD5 | VGNC | VGNC:70770 |
| Canis familiaris | CD5 | VGNC | VGNC:38962 |
| Others | CD5 | NCBI |