Ece1 - endothelin converting enzyme 1 Gene

Also Known as Ece

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 94204

Summary

Enables identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Located in early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]

Ece1 Products (1)

mRNA	Protein	Name
NM_053596.2	NP_446048.2	endothelin-converting enzyme 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	8645169	RGD

Biological Process GO Annotation	Evidence	Verweise	Source
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	22881710	RGD
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15733912	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	22881710	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	20099522	RGD
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	21878523	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	8034569	RGD
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21878523	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19596829	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	12189509	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	11813889	RGD
involved in response to muscle stretch	IEP IEP: Inferred from expression pattern	16410403	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11145282	RGD

Cellular Component GO Annotation	Evidence	Verweise	Source
located in early endosome	IDA IDA: Inferred from direct assay	22881710	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9449382	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	11813889	RGD
located in vesicle	IDA IDA: Inferred from direct assay	9449382	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
endothelin-converting enzyme 1	ECE-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B1237	Suloctidil	Inhibitor	99.96%	Unkown
HY-P3749	Mca-(ala7,lys(dnp)9)-bradykinin		99.93%	Unkown
HY-N11772	Mutanocyclin	Inhibitor	99.94%	Unkown
HY-107762	CGS35066	Inhibitor	/	Unkown
HY-119545	PD159790	Inhibitor	/	Unkown
HY-178732	AB-22	Inhibitor	/	Unkown
HY-184728	Antifungal agent-169	Inhibitor	/	Unkown
HY-RS04133	ECE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18211	CGS 35601	Inhibitor	/	Unkown
HY-RS18611	Ece1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25097	Ece1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ece1	NCBI	NCBI:1889