CHST2 - carbohydrate sulfotransferase 2 Gene

Also Known as C6ST; GST2; GST-2; Gn6ST-1; HEL-S-75; glcNAc6ST-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9435

About CHST2

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:143,119,771-143,124,014 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues and 6 paralogues. Broad expression in spleen (RPKM 8.2), placenta (RPKM 6.8) and 22 other tissues.

Summary

This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]

CHST2 Products (1)

mRNA Protein Name
NM_004267.5 NP_004258.2 carbohydrate sulfotransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
IDA: Inferred from direct assay
9722682 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acetylglucosamine metabolic process IDA
IDA: Inferred from direct assay
9722682 GOA
involved in sulfur compound metabolic process IDA
IDA: Inferred from direct assay
9722682 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12855678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST2 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (168 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
Protein Preferred Names Protein Names

carbohydrate sulfotransferase 2

  • N-acetylglucosamine 6-O-sulfotransferase 1

Related Diseases

Diseases Alias
Childhood Malignant Schwannoma

  • Pediatric Mpnst

  • Childhood Neurofibrosarcoma
Cholangiolocellular Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02688 CHST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CHST2 VGNC VGNC:71056
Felis catus CHST2 VGNC VGNC:82352
Mus musculus CHST2 MGD MGI:1891160
Rattus norvegicus CHST2 RGD RGD:1306988
Bos taurus CHST2 VGNC VGNC:27344
Canis familiaris CHST2 VGNC VGNC:39254
Others CHST2 NCBI