NCR1 - natural cytotoxicity triggering receptor 1 Gene

Homo sapiens

Also known as LY94; CD335; NKP46; NK-p46

Gene ID: 9437 | Gene type: protein coding

About NCR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,898,198-54,938,208 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues.

Summary

Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Apr 2022]

NCR1 Products(5)

mRNA	Protein	Name
NM_001145457.3	NP_001138929.2	natural cytotoxicity triggering receptor 1 isoform b precursor
NM_001145458.3	NP_001138930.2	natural cytotoxicity triggering receptor 1 isoform c precursor
NM_001242356.3	NP_001229285.1	natural cytotoxicity triggering receptor 1 isoform d precursor
NM_001242357.3	NP_001229286.1	natural cytotoxicity triggering receptor 1 isoform e precursor
NM_004829.7	NP_004820.2	natural cytotoxicity triggering receptor 1 isoform a precursor

NCR1 Protein Structure

Ig_2

Ig_3

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

natural cytotoxicity triggering receptor 1

NK cell-activating receptor

Recombinant NCR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70174	NKp46/NCR1 Protein, Human (HEK293, Fc)	O76036-6/AAH64806 (Q22-D254)	≥95%
HY-P77810	NKp46/NCR1 Protein, Human (HEK293, His)	O76036-6/AAH64806 (Q22-D254)	≥95%
HY-P78008	NKp46/NCR1 Protein, Human (HEK293, mFc)	O76036 (Q22-N255)	≥95%
HY-P78830	NKp46/NCR1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	AAH64806 (Q22-N254)	≥95%
HY-P78832	NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His)	O76036 (Q22-N254)	≥95%

Related Diseases

Diseases

Alias

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole	Gestational Trophoblastic Disease
Complete Hydatidiform Mole	Hydm
HYDM1	Chm
Molar Pregnancy	Hydatidiform Mole, Complete
Hydatid Mole	Complete Molar Pregnancy
Mole, Hydatidiform, Recurrent, Type 1	Gestational Trophoblastic Neoplasms
Hydatidiform Mole, Recurrent, 2	Classical Hydatidiform Mole

Anogenital Venereal Wart

Genital Warts	Condylomata Acuminata
Anogenital Warts	Condyloma Acuminatum
Anogenital Human Papilloma Virus Infectious Disease	Genital Wart Virus Infectious Disease
Venereal Wart	Venereal Warts
Verrucae Anogenitales	Verrucae Genitales

Nk Cell Deficiency

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome	AIDS
Acquired Immune Deficiency	Acquired Immunodeficiency
Acquired Immunodeficiency Due To Protein Loss

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Cd3zeta Deficiency

Bronchiectasis 1

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09098	NCR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCR1	RGD	RGD:621288
Mus musculus	NCR1	MGD	MGI:1336212
Bos taurus	NCR1	VGNC	VGNC:31926
Canis familiaris	NCR1	VGNC	VGNC:53740
Macaca mulatta	NCR1	VGNC	VGNC:75065
Macaca fascicularis	NCR1	NCBI
Others	NCR1	NCBI