NCR1 - natural cytotoxicity triggering receptor 1 Gene

Also Known as LY94; CD335; NKP46; NK-p46

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9437

About NCR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,898,198-54,938,208 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues.

Summary

Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Apr 2022]

NCR1 Products (5)

mRNA Protein Name
NM_001145457.3 NP_001138929.2 natural cytotoxicity triggering receptor 1 isoform b precursor
NM_001145458.3 NP_001138930.2 natural cytotoxicity triggering receptor 1 isoform c precursor
NM_001242356.3 NP_001229285.1 natural cytotoxicity triggering receptor 1 isoform d precursor
NM_001242357.3 NP_001229286.1 natural cytotoxicity triggering receptor 1 isoform e precursor
NM_004829.7 NP_004820.2 natural cytotoxicity triggering receptor 1 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17056548 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 117)

Ig_3

Ig_3: Immunoglobulin domain (124 - 193)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 1

  • NK cell-activating receptor

NCR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCR1 O76036 P27918-PRO_0000035863 Homo sapiens P27918-PRO_0000035863
FACS
28480349
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR1 Proteins

Cat. No. Product Name Accession Purity
HY-P70174 NKp46/NCR1 Protein, Human (HEK293, Fc) AAH64806 (Q22-N254) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77810 NKp46/NCR1 Protein, Human (HEK293, His) AAH64806 (Q22-N254) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78008 NKp46/NCR1 Protein, Human (HEK293, mFc) O76036-1 (Q22-N255) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78830 NKp46/NCR1 Protein, Human (Biotinylated, HEK293, Fc-Avi) AAH64806 (Q22-N254) ≥ 95%, as determined by reducing SDS-PAGE.

NCR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81447 NCR1 Antibody (YA1192) IHC-P Human
HY-P81447A NCR1 Antibody (YA1192)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Gestational Trophoblastic Neoplasm

  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos
Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole

  • Gestational Trophoblastic Disease

  • Complete Hydatidiform Mole

  • Hydm

  • HYDM1

  • Chm

  • Molar Pregnancy

  • Hydatidiform Mole, Complete

  • Hydatid Mole

  • Complete Molar Pregnancy

  • Mole, Hydatidiform, Recurrent, Type 1

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 2

  • Classical Hydatidiform Mole
Anogenital Venereal Wart

  • Genital Warts

  • Condylomata Acuminata

  • Anogenital Warts

  • Condyloma Acuminatum

  • Anogenital Human Papilloma Virus Infectious Disease

  • Genital Wart Virus Infectious Disease

  • Venereal Wart

  • Venereal Warts

  • Verrucae Anogenitales

  • Verrucae Genitales
Nk Cell Deficiency
Newcastle Disease

  • Newcastle'S Disease

  • Pseudo-Fowlpest
Acquired Immunodeficiency Syndrome

  • Acquired Immune Deficiency Syndrome

  • AIDS

  • Acquired Immune Deficiency

  • Acquired Immunodeficiency

  • Acquired Immunodeficiency Due To Protein Loss
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Lymphoproliferative Syndrome

  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To
Cd3zeta Deficiency
Bronchiectasis 1
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990905 Bexatamig Inhibitor 97.06% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09098 NCR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17588 Ncr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24048 Ncr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991326 BL-9020 Inhibitor 98.32% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCR1 RGD RGD:621288
Mus musculus NCR1 MGD MGI:1336212
Bos taurus NCR1 VGNC VGNC:31926
Canis familiaris NCR1 VGNC VGNC:53740
Macaca mulatta NCR1 VGNC VGNC:75065
Others NCR1 NCBI