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Bexatamig

(Synonyms: SAR-443579)
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Based on 1 Customer Validation

Bexatamig (SAR-443579) is a trifunctional natural killer cell engager targeting IL-3R α/CD123, NKp46/NCR1/CD335 and Fc gamma RIIIA/CD16a. Bexatamig forms a cytolytic synapse between natural killer cells and CD123-positive tumor cells. By activating natural killer cells to induce tumor cell death, Bexatamig effectively reduces the burden of CD123-positive acute myeloid leukemia (AML) blasts. Bexatamig has been granted FDA Fast Track designation, and is primarily investigated for relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, and high-risk myelodysplastic syndromes.

For research use only. We do not sell to patients.

  • Purity: 97.06%
  • CAS No.: 2871775-98-1
  • Molecular Weight:170.838 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Bexatamig Chemical Structure
  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Experimental Validation Results for Bexatamig
  • Bexatamig Chemical Structure
    Bexatamig Chemical Structure
CAS No.: 2871775-98-1
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    VH-Vkappa-G1Fc-Fab

  • 1/16

    Immobilized IL-3R alpha/CD123 Protein, Human (HEK293, His, HY-P70468) can bind Bexatamig. The EC50 for this effect is 37.04 ng/mL.

  • 1/16

    Immobilized NKp46/NCR1 Protein, Human (HEK293, His, HY-P77810) can bind Bexatamig. The EC50 for this effect is 35.75 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HepG2 cells labeling IL3RA with Bexatamig (HY-P990905, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Bexatamig Chemical Structure
    1/16
  • Bexatamig
  • Immobilized IL-3R alpha/CD123 Protein, Human (HEK293, His, HY-P70468) can bind Bexatamig. The EC50 for this effect is 37.04 ng/mL.
  • Immobilized NKp46/NCR1 Protein, Human (HEK293, His, HY-P77810) can bind Bexatamig. The EC50 for this effect is 35.75 ng/mL.
  • Flow cytometric analysis of 1X106 HepG2 cells labeling IL3RA with Bexatamig (HY-P990905, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • VH-Vkappa-G1Fc-Fab