PCLAF - PCNA clamp associated factor Gene

Also Known as L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9768

About PCLAF

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,364,304-64,387,687 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Biased expression in bone marrow (RPKM 26.4), lymph node (RPKM 13.8) and 11 other tissues.

Summary

Enables chromatin binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCLAF Products (2)

mRNA Protein Name
NM_001029989.3 NP_001025160.1 PCNA-associated factor isoform 2
NM_014736.6 NP_055551.1 PCNA-associated factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23000965 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
25762514 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
25762514 GOA
enables molecular adaptor activity IPI
IPI: Inferred from physical interaction
25762514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21628590 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
21628590 GOA
involved in DNA replication IDA
IDA: Inferred from direct assay
23000965 GOA
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
21673012 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
21628590 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
23000965 GOA
involved in translesion synthesis IMP
IMP: Inferred from mutant phenotype
23000965 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21628590 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21673012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PCNA-associated factor

  • HCV NS5A-transactivated protein 9

PCLAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCLAF Q15004 PCNA Homo sapiens P12004
Y2H Array
32296183
Intra
PCLAF Q15004 PCNA Homo sapiens P12004
Y2H Prey Pooling
32296183
Intra
PCLAF Q15004 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra
PCLAF Q15004 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCLAF Proteins

Cat. No. Product Name Accession Purity
HY-P75900 KIAA0101 Protein, Human (His) Q15004-1 (M1-E111) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Phlyctenulosis

  • Phlyctenular Keratoconjunctivitis

  • Strumous Ophthalmia
Anomalous Left Coronary Artery From The Pulmonary Artery

  • Bland White Garland Syndrome

  • Alcapa

  • Bland-White-Garland Syndrome

  • White-Garland Syndrome
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149428 AD4 98.01% Unkown
HY-162393 XL44 Activator 99.76% Unkown
HY-174301 USP7-IN-18 / Unkown
HY-RS10154 PCLAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19227 Pclaf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25716 Pclaf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PCLAF MGD MGI:1915276
Rattus norvegicus PCLAF RGD RGD:1303041
Others PCLAF NCBI