2. Apoptosis
  3. Apoptosis
  4. GL392

GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib (HY-10181) to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. GL392 in micelle encapsulation (mGL392) enables selective delivery to senescent cells, achieving selective senescent cell elimination in vitro and in vivo. GL392 can be used for the research of melanoma.

For research use only. We do not sell to patients.

GL392

GL392 Chemical Structure

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GL392 Related Antibodies

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Description

GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib (HY-10181) to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. GL392 in micelle encapsulation (mGL392) enables selective delivery to senescent cells, achieving selective senescent cell elimination in vitro and in vivo. GL392 can be used for the research of melanoma[1].

In Vitro

mGL392 (20-160 nM, 4 days) does not affect non-senescent B16 melanoma growth[1].
mGL392 (10 nM) selectively accumulates within senescent cells in HBEC CDC6 Tet-ON and Li-Fraumeni-p21WAF1/Cip1 Tet-ON cells[1].
mGL392 (500 nM, 4 days) induces targeted senolysis in 3D patient-derived lung organoids[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GL392 Related Antibodies

Cell Viability Assay[1]

Cell Line: B16 cells
Concentration: 20, 80, 160 nM
Incubation Time: 4 days
Result: Showed no affect on non-senescent B16 melanoma growth.
In Vivo

GL392 (0.015 mg; i.p.; daily; 9 days) induces selective senolysis in Palbociclib (HY-50767)-induced senescent melanoma cells in mice, reducing tumor volume by targeting senescent cells without systemic toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (8-10 weeks old) subcutaneously injected with B16 melanoma cells, followed by Palbociclib-induced senescence[1]
Dosage: 0.015 mg per mouse
Administration: i.p.; daily; 9 days
Result: Reduced tumor volume significantly.
Induced tumor cell apoptosis.
Did not affect non-senescent B16 melanoma cell viability in vivo when senescence was absent.
Left serum markers of liver, kidney, and muscle function (including ALP, AST/ALT ratio, and CPK) within normal ranges, with no histopathological damage to vital organs observed.
Molecular Weight

1042.60

Formula

C55H52ClN13O5S
SMILES

CC1(COC(CCC(OCCN2CCN(C3=CC(NC4=NC=C(C(NC5=C(C)C=CC=C5Cl)=O)S4)=NC(C)=N3)CC2)=O)=O)NC6=CC=CC(C6=C(N1)C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GL392 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GL392GL 392GL-392Apoptosissenolytic compoundesterasemicelle encapsulationpalbocicliblipofuscinmelanomasenescent cellsdasatinibInhibitorinhibitorinhibit

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