2. GPCR/G Protein Neuronal Signaling
  3. GPR119
  4. GPR119 agonist 4

GPR119 agonist 4 is a GPR119 agonist and oral glucose-lowering agent with a human GPR119 EC50 of 42 nM.GPR119 agonist 4 activates GPR119.GPR119 agonist 4 reduces blood glucose area under the curve in an oral glucose tolerance test.GPR119 agonist 4 exhibits improved clearance in liver microsomes.GPR119 agonist 4 can be used for the research of type 2 diabetes mellitus.

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GPR119 agonist 4

GPR119 agonist 4 Chemical Structure

CAS No. : 1353004-92-8

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GPR119 agonist 4 Related Antibodies

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Description

GPR119 agonist 4 is a GPR119 agonist and oral glucose-lowering agent with a human GPR119 EC50 of 42 nM.GPR119 agonist 4 activates GPR119.GPR119 agonist 4 reduces blood glucose area under the curve in an oral glucose tolerance test.GPR119 agonist 4 exhibits improved clearance in liver microsomes.GPR119 agonist 4 can be used for the research of type 2 diabetes mellitus[1].

In Vitro

GPR119 agonist 4 (Compound 26) has improved metabolic stability, with clearance values of 113 μL/min/mg/protein in human liver microsomes and 108 μL/min/mg/protein in mouse liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPR119 agonist 4 Related Antibodies
Parmacokinetics
Species Dose Route CLplasma Vss T1/2 Cmax AUC Bioavailability
Mice[1] 0.5 mg/kg i.v. 6.5 mL/min/kg 2.3 L/kg 5.1 h / / /
Mice[1] 10 mg/kg p.o. / / / 2015 ng/mL 9386 ng·h/mL 37 %
In Vivo

GPR119 agonist 4 (Compound 26) (10 mg/kg; p.o.; single dose) induces a 33% reduction in blood glucose AUC0-t at a dose of 10 mg/kg in an oral glucose tolerance test in C57BL/6N mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6N mice[1]
Dosage: 10 mg/kg
Administration: p.o.; single dose
Result: Induced a 33% reduction in blood glucose area under the curve (AUC) during the oral glucose tolerance test.
Molecular Weight

511.00

Formula

C24H23ClN6O3S
CAS No.
SMILES

O=S(C1=CC=C2C(CCN2C3=NC=NC4=C3OC=C4C5CCN(CC5)C6=NC=C(C=N6)Cl)=C1)(C)=O
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Purity & Documentation
References
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GPR119 agonist 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR119 agonist 41353004-92-8GPR119G Protein-Coupled Receptor 119human liver microsomestype 2 diabetes mellitusC57BL/6N miceliver microsomeshuman GPR119oral glucose tolerance testmouse liver microsomesInhibitorinhibitorinhibit

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