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Cat. No.: HY-187164

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HCV NS5B polymerase-IN-5

HCV NS5B polymerase-IN-5 is a HCV NS5B polymerase inhibitor with an IC₅₀ value of 47.9 μM. HCV NS5B polymerase-IN-5 reduces the production of inorganic pyrophosphate and decreases the nucleoside triphosphate incorporation of HCV NS5B polymerase. HCV NS5B polymerase-IN-5 can be used in studies related to hepatitis C virus infection.

For research use only. We do not sell to patients.

CAS No.: 78945-99-0
Formula: C₁₆H₁₁NO₃
Molecular Weight:265.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HCV NS5B polymerase-IN-5 Chemical Structure

CAS No.: 78945-99-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>150 μM	Cytotoxicity against human parental Huh-7 cells assessed as cell survival via MTT reduction after 48 h of treatment. Cytotoxicity against human parental Huh-7 cells assessed as cell survival via MTT reduction after 48 h of treatment.	22204334

In Vitro

HCV NS5B polymerase-IN-5 (11d) (escalating concentrations; 30 min pre-incubation, 60 min assay incubation) weakly inhibits recombinant HCV genotype 1b NS5B polymerase in the PPi generation assay with an IC₅₀ of 47.9 μM^[1].
HCV NS5B polymerase inhibitor 5 (11d) (0, 1, 10 μM; 48 h) shows no cytotoxicity against parental Huh-7 cells (CC₅₀ > 150 μM) and no detectable anti-HCV activity against HCV genotype 1b replicon Ava.5 cells (EC₅₀ > 150 μM) after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HCV genotype 1b replicon Ava.5 cells, parental Huh-7 cells
Concentration:

0, 1, 10 μM
Incubation Time:

48 h
Result:

Exhibited no cytotoxicity against parental Huh-7 cells (CC₅₀ > 150 μM).
Showed no measurable antiviral activity against HCV replicon Ava.5 cells (EC₅₀ > 150 μM).

Chemical Information

CAS No. 78945-99-0
Molecular Weight 265.26
Formula C₁₆H₁₁NO₃
SMILES

O=C(C(N1)=C(C2=CC=CC=C2)C3=C(C=CC=C3)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Deore RR, et al. 2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with inbuilt β-N-hydroxy-γ-keto-acid pharmacophore as HCV NS5B polymerase inhibitors. Current medicinal chemistry. 2012;19(4):613-24.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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