2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC8-IN-6

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC50 of 5.1 μM. HDAC8-IN-6 shows cytotoxicity.

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HDAC8-IN-6

HDAC8-IN-6 화학구조

CAS No. : 3036403-81-0

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HDAC8-IN-6 Related Antibodies

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제품 설명

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC50 of 5.1 μM. HDAC8-IN-6 shows cytotoxicity[1].

IC50 & Target[1]

HDAC8

5.1 μM (IC50)

HDAC4

23.1 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEL IC50
> 200 μM
Compound: 3
Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
HL-60 IC50
161 μM
Compound: 3
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
MOLM-13 IC50
7.08 μM
Compound: 3
Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
MV4-11 IC50
8.23 μM
Compound: 3
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
OCI-AML-3 IC50
27.17 μM
Compound: 3
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
SET-2 IC50
> 200 μM
Compound: 3
Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
THP-1 IC50
46.5 μM
Compound: 3
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
[PMID: 38113354]
분자량

447.27

화학식

C19H18IN3O2
CAS No.
SMILES

C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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HDAC8-IN-6 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-63036403-81-0HDACHistone deacetylasesTHP-1HL-60cytotoxicityInhibitorinhibitorinhibit

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상품명:
HDAC8-IN-6
Cat. No.:
HY-163143
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