hsa-miR-33a-5p antagomir
Based on 1 Customer Validation
hsa-miR-33a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
For research use only. We do not sell to patients.
- Molecular Weight:7014.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) hsa-miR-33a-5p antagomir
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Biological Activity
Chemical Information
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Molecular Weight 7014.58
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
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miRBase Accession Number
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Mature miRNA Sequence
GUGCAUUGUAGUUGCAUUGCA
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Stem-loop ID
hsa-mir-33a
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Stem-loop Sequence
CUGUGGUGCAUUGUAGUUGCAUUGCAUGUUCUGGUGGUACCCAUGCAAUGUUUCCACAGUGCAUCACAG
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Species
Human, Mouse, Rat, Aedes aegypti, Alligator mississippiensis, Anolis carolinensis, Anopheles gambiae, Bombyx mori, Bovine, Branchiostoma belcheri, Capitella teleta, Chrysemys picta, Columba livia, Culex quinquefasciatus, Dasypus novemcinctus, Dinoponera quadriceps, Gadus morhua, Guinea pig, Horse, Manduca sexta, Monodelphis domestica, Oreochromis niloticus, Pteropus alecto, Python bivittatus, Rabbit, Salmo salar, Triops cancriformis, Tupaia chinensis, Xenopus laevis
Publications (1)
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Journal Impact Factor
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Most Recent
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Glia
Lysosomal cholesterol accumulation in aged astrocytes impairs cholesterol delivery to neurons and can be rescued by cannabinoids. [Abstract]2024 Oct;72(10):1746-1765. PMID: 38856177
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)