2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP90-IN-10

HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis.

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HSP90-IN-10

HSP90-IN-10 화학구조

CAS No. : 2881071-86-7

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제품 설명

HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
HCC1954 IC50
6 μM
Compound: 16s
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay
[PMID: 34844036]
HCC1954 IC50
6 μM
Compound: 16s
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay
[PMID: 34844036]
MCF-10A IC50
> 30 μM
Compound: 16s
Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay
[PMID: 34844036]
MCF7 IC50
6.2 μM
Compound: 16s
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 34844036]
MDA-MB-231 IC50
> 25 μM
Compound: 16s
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
[PMID: 34844036]
분자량

543.54

화학식

C30H26FN3O6
CAS No.
SMILES

COC1=CC(C2=C3C(CC(C)(C/C3=N\OC(C4=CC(NC(C5=CC(F)=CC=C5)=O)=CC=C4)=O)C)=NO2)=CC=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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HSP90-IN-10 Related Classifications

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Keywords:

HSP90-IN-102881071-86-7HSPApoptosisHeat shock proteinsHSP90antiproliferativebreast cancerepithelialapoptosisInhibitorinhibitorinhibit

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HSP90-IN-10
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HY-144724
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