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Cat. No.: HY-103078R

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I-XW-053 (Standard)

I-XW-053 (Standard) is the analytical standard of I-XW-053 (HY-103078). This product is intended for research and analytical applications. I-XW-053 is a specific anti-HIV-1 capsid inhibitor (IC₅₀=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (K_d=66.3 μM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 5496-35-5
Formula: C₂₂H₁₆N₂O₂
Molecular Weight:340.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

I-XW-053 (Standard) Chemical Structure

CAS No.: 5496-35-5

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 5496-35-5
Molecular Weight 340.38
Formula C₂₂H₁₆N₂O₂
SMILES

O=C(O)C1=CC=C(C=C1)C2=NC(C=3C=CC=CC3)=C(N2)C=4C=CC=CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kortagere S, et al. Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012;86(16):8472-8481. [Content Brief]

[2]. Chia T, et al. A Small Molecule, ACAi-028, with Anti-HIV-1 Activity Targets a Novel Hydrophobic Pocket on HIV-1 Capsid. Antimicrob Agents Chemother. 2021;65(10):e0103921. [Content Brief]

[3]. Fricke T, et al. Human cytosolic extracts stabilize the HIV-1 core. J Virol. 2013;87(19):10587-10597. [Content Brief]

[4]. Kortagere S, et al. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication. J Chem Inf Model. 2014;54(11):3080-3090. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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